Conference proceeding
Quantifying age-related changes in the structure and mechanical function of skin with multiscale imaging
Multiscale Imaging and Spectroscopy III
03/07/2022
DOI: 10.1117/12.2610110
Abstract
Second-harmonic generation microscopy and macro-scale imaging were combined to enable multiscale assessments of mouse skin undergoing uniaxial mechanical testing. Skin from old and young mice experienced a substantial micro-scale volume reduction during uniaxial tension. A non-affine relationship between the 3D collagen fiber kinematics and local deformation was also observed. Aged skin was found to have a lower stiffness but increased collagen fiber realignment during mechanical loading. These results are being used to develop multiscale models of skin mechanics and obtain a more complete understanding of age-related changes in skin structure-function relationships.
Details
- Title: Subtitle
- Quantifying age-related changes in the structure and mechanical function of skin with multiscale imaging
- Creators
- Alan E. Woessner - University of Arkansas at FayettevilleJake D. Jones - University of Arkansas at FayettevilleNathan J. Witt - University of IowaEdward A. Sander - University of IowaKyle P. Quinn - University of Arkansas at Fayetteville
- Resource Type
- Conference proceeding
- Publication Details
- Multiscale Imaging and Spectroscopy III
- DOI
- 10.1117/12.2610110
- Publisher
- SPIE
- Language
- English
- Date published
- 03/07/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984530558202771
Metrics
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