REAL-TIME MONITORING OF INSULIN USING A GRAPHENE APTAMERIC NANOSENSOR

Zhuang Hao; Yibo Zhu; Xuejun Wang; Pavana Rotti; Christopher Dimarco; Shuyu Lin; Xuezeng Zhao; John Engelhardt; James Hone; Qiao Lin

doi:10.1109/MEMSYS.2017.7863425

Conference proceeding

REAL-TIME MONITORING OF INSULIN USING A GRAPHENE APTAMERIC NANOSENSOR

Zhuang Hao, Yibo Zhu, Xuejun Wang, Pavana Rotti, Christopher Dimarco, Shuyu Lin, Xuezeng Zhao, John Engelhardt, James Hone and Qiao Lin

30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2017), pp.398-401

Proceedings IEEE Micro Electro Mechanical Systems

01/01/2017

DOI: 10.1109/MEMSYS.2017.7863425

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Abstract

We present a new approach for real-time, specific and sensitive detection of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a graphene field effect transistor, where the graphene conducting channel was functionalized with a guanine-rich aptamer IGA3 that would form an anti-parallel G-quadruplex upon insulin binding. The aptamer conformational changes altered the electrical conductance of graphene by varying the carrier density of the graphene. The nanosensor allowed us to perform real-time, label-free and specific detection of insulin concentrations as low as 1 nM.

Engineering

Technology

Engineering, Electrical & Electronic

Engineering, Mechanical

Nanoscience & Nanotechnology

Science & Technology

Science & Technology - Other Topics

Details

Title: Subtitle: REAL-TIME MONITORING OF INSULIN USING A GRAPHENE APTAMERIC NANOSENSOR
Creators: Zhuang Hao - Columbia University
Yibo Zhu - Columbia University
Xuejun Wang - Columbia University
Pavana Rotti - Roy J. and Lucille A. Carver College of Medicine
Christopher Dimarco - Columbia University
Shuyu Lin - Columbia University
Xuezeng Zhao - Harbin Institute of Technology
John Engelhardt - Roy J. and Lucille A. Carver College of Medicine
James Hone - Columbia University
Qiao Lin - Columbia University
Resource Type: Conference proceeding
Publication Details: 30th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2017), pp.398-401
Publisher: IEEE
Series: Proceedings IEEE Micro Electro Mechanical Systems
DOI: 10.1109/MEMSYS.2017.7863425
ISSN: 1084-6999
Number of pages: 4
Grant note: 201506120133 / China Scholarship Council ECCS-1509760 / National Science Foundation; National Science Foundation (NSF) 1DP3 DK101085-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 01/01/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Internal Medicine; Anatomy and Cell Biology; Radiation Oncology
Record Identifier: 9984284335602771

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