Conference proceeding
Registration-based regional lung mechanical analysis: retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition
Proceedings of SPIE, Vol.7262(1), pp.72620D-72620D-9
Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
02/26/2009
DOI: 10.1117/12.813694
Abstract
The lungs undergo expansion and contraction during the respiratory cycle. Since many disease or injury conditions are associated with the biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation and regional mechanical changes. We describe a technique that uses multiple respiratory-gated CT images and non-rigid 3D image registration to make local estimates of lung tissue expansion. The degree of regional lung expansion is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field. We compare the ventral-dorsal patterns of lung expansion estimated in both retrospectively reconstructed dynamic scans and static breath-hold scans to a xenon CT based measure of specific ventilation and a semi-automatic reference standard in four anesthetized sheep studied in the supine orientation. The regional lung expansion estimated by 3D image registration of images acquired at 50% and 75% phase points of the inspiratory portion of the respiratory cycle and 20 cm H
O and 25 cm H
O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation respectively (linear regression, average r
= 0.85 and r
= 0.84). The registration accuracy assessed by 200 semi-automatically matched landmarks in both the dynamic and static scans show landmark error on the order of 2 mm.
Details
- Title: Subtitle
- Registration-based regional lung mechanical analysis: retrospectively reconstructed dynamic imaging versus static breath-hold image acquisition
- Creators
- Kai Ding - University of IowaKunlin Cao - University of IowaGary E Christensen - University of IowaEric A Hoffman - University of IowaJoseph M Reinhardt - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.7262(1), pp.72620D-72620D-9
- Conference
- Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
- DOI
- 10.1117/12.813694
- ISSN
- 0277-786X
- Language
- English
- Date published
- 02/26/2009
- Academic Unit
- The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Electrical and Computer Engineering; Roy J. Carver Department of Biomedical Engineering; Holden Comprehensive Cancer Center; Internal Medicine; Radiology; Radiation Oncology; Radiation Research Laboratory
- Record Identifier
- 9984196977502771
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