Conference proceeding
Relationship between plaque development and local hemodynamics in coronary arteries
Proceedings of SPIE, Vol.5746(1), pp.223-232
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
04/14/2005
DOI: 10.1117/12.596902
Abstract
The mechanisms of plaque development in coronary arteries are not yet
completely understood. Vessel geometry influences the local hemodynamics within a vessel, and the resulting wall shear stress in turn influences plaque development. Previously, we showed in-vivo that plaque tends to accumulate more on the inner curvature of a vessel than on its outer curvature. While vessel curvature is preserved during plaque progression, the local wall shear stresses change with lumen narrowing. The aim of this study was to test how the hypothesis that locations of low wall shear stress coincide with circumferentially larger plaque accumulation depends on vascular remodeling with or without lumen narrowing. We have analyzed
39 in-vivo intravascular-ultrasound pullbacks, for which geometrically
accurate 3-D models were obtained by fusion with x-ray angiography.
Distorting subsegments (branches, calcifications, stents) were discarded, and the relative number of vessel locations was determined within a 10-40% area-stenosis range. This range corresponds to
(outward or positive vessel remodeling), but not yet lumen narrowing, and these vessel segments were a focus of our study. For each segment, we determined the relative number of vessel locations for which circumferentially low wall shear stress coincided with larger plaque thickness and vice versa. The inverse association between wall shear stress and plaque thickness was significantly more pronounced (
<0.005) in vessel cross sections exhibiting compensatory enlargement without luminal narrowing than when the full spectrum of vessel stenosis severity was considered. Thus, the hypothesis is supported more in subsegments with less developed disease.
Details
- Title: Subtitle
- Relationship between plaque development and local hemodynamics in coronary arteries
- Creators
- Andreas Wahle - University of IowaJohn J Lopez - University of ChicagoMark E Olszewski - University of IowaSarah C Vigmostad - University of IowaKathleen C Braddy - University of IowaTheresa M. H Brennan - University of IowaSyed W Bokhari - The Univ. of Chicago (USA)J. Gray Bennett - University of ChicagoElizabeth M Holper - University of ChicagoJames D Rossen - University of IowaKrishnan B Chandran - University of IowaMilan Sonka - University of Iowa
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5746(1), pp.223-232
- Conference
- Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
- DOI
- 10.1117/12.596902
- ISSN
- 0277-786X
- Language
- English
- Date published
- 04/14/2005
- Academic Unit
- Neurology; Electrical and Computer Engineering; Surgery; Injury Prevention Research Center; Mechanical Engineering; Roy J. Carver Department of Biomedical Engineering; Cardiovascular Medicine; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186601702771
Metrics
14 Record Views