Conference proceeding
Simplified and reproducible radiochemical separations for the production of high specific activity Cu-61, Cu-64, Y-86 and Co-55
WTTC16: Proceedings of the 16th International Workshop on Targetry and Target Chemistry, Vol.1845
AIP Conference Proceedings
01/01/2017
DOI: 10.1063/1.4983552
Abstract
Four positron-emitting radiometals Cu-61, Cu-64, Y-86 and Co-55 are increasingly being employed as labels for positron emission tomography (PET) imaging due to their favorable half-lives that match the pharmacokinetics of targeting moeities such as peptides, antibodies and antibody fragments and due to their use in internal dosimetry and treatment planning of targeted radionuclide therapy when they are substituted by their therapeutic analogues Cu-67, Y-90 and (58)mCo. The main disadvantage of the production methods reported in the literature for these radionuclides is that the final separated radioactive product is diluted in a large volume (> 5 mL), which obligates a lengthy evaporation step in a large vessel that is difficult to automate in-line after the chromatographic steps and that results in a highly variable amount of radioactivity lost in the vessel's surface. In this work we present simplified radiochemical separation methods for the production of Cu-61, Cu-64, Y-86 and Co-55 that result in: 1) a final eluate volume <= 600 mu L; 2) reproducible separation yields of 84 +/- 4%, 82 +/- 6%, 94 +/- 5% and 93 +/- 6%, respectively; and 3) effective specific activities of 64.0 +/- 45.0 GBq/mu mol NOTA, 114.9 +/- 40.1 GBq/mu mol NOTA, 1.4 +/- 0.5 GBq/mu mol DTPA and 10.1 +/- 5.7 GBq/mu mol NOTA, respectively; without compromising the recycling efficiencies of the respective isotopically-enriched target materials Ni-60, Ni-64, (SrCO3)-Sr-86 and Ni-58, which accounted for 98 +/- 1%, 96 +/- 3%, 90 +/- 3% and 94 +/- 1%, respectively.
Details
- Title: Subtitle
- Simplified and reproducible radiochemical separations for the production of high specific activity Cu-61, Cu-64, Y-86 and Co-55
- Creators
- Hector F. Valdovinos - University of Wisconsin–MadisonStephen Graves - University of Wisconsin–MadisonTodd Barnhart - University of Wisconsin–MadisonRobert J. Nickles - University of Wisconsin–Madison
- Contributors
- J W Engle (Editor)T E Barnhart (Editor)F M Nortier (Editor)J P ONeil (Editor)E R Birnbaum (Editor)K M Gangon (Editor)
- Resource Type
- Conference proceeding
- Publication Details
- WTTC16: Proceedings of the 16th International Workshop on Targetry and Target Chemistry, Vol.1845
- Publisher
- Amer Inst Physics
- Series
- AIP Conference Proceedings
- DOI
- 10.1063/1.4983552
- ISSN
- 0094-243X
- eISSN
- 1551-7616
- Number of pages
- 6
- Grant note
- DOE Office of Science; United States Department of Energy (DOE) 5 T32 CA009206-32 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA DE-SC0008384 / US Department of Energy; United States Department of Energy (DOE)
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Radiation Oncology; Radiology; Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984383927202771
Metrics
33 Record Views