Conference proceeding
Spectroscopic Photoacoustic Imaging for Accessing Cervical Tissue Composition in Human Cervical Biopsies
2021 IEEE International Ultrasonics Symposium (IUS), pp.1-4
09/11/2021
DOI: 10.1109/IUS52206.2021.9593345
Abstract
The cervix plays a central role in pregnancy and delivery. A short cervix ( \leqslant 25\ \text{mm} ), measured by ultrasound (US) imaging, at gestational ages between 22 to 24 weeks indicates a higher risk for preterm birth (PTB). Our previous publications had determined that a spectroscopic photoacoustic (sPA) imaging method in the near-infrared range has the potential to quantify the cervical remodeling as the collagen to water ratio (CWR) changes in murine cervices. Herein, we present the continuous study of the sPA method to identify un-ripened and ripened cervices in humans. A cross-sectional study was performed in comprised cervical biopsies obtained at the time of hysterectomy ( \mathrm{n}=8 ) and at the scheduled cesarean delivery in pregnant women at term who were not in labor ( \mathrm{n}=8 ). The results indicated that the average sPA-CWR in the cervical tissue from non-pregnant women is 55.5%, with a standard deviation (SD) of 20.3%. On the contrary, pregnant women have an average sPA-CWR of 18.7%, with an SD of 7.5%. The statistical analysis shows a significant difference between those two groups with a p-value less than 0.001. Furthermore, a sub-group analysis between pregnant and non-pregnant women of age less than or equal to 41 years old also showed a significant difference in the sPA-CWR with a p-value less than 0.001, mean 46.3%, SD 23.1%. Through histological analysis, the pregnant women group had lower collagen content. Therefore, the sPA method shows promise to become a new potential diagnostic indicator for evaluating cervical tissue composition and its association with the risk of cervical abnormalities leading to preterm birth.
Details
- Title: Subtitle
- Spectroscopic Photoacoustic Imaging for Accessing Cervical Tissue Composition in Human Cervical Biopsies
- Creators
- Yan Yan - Wayne State UniversityMaryam Basij - Wayne State UniversityAlpana Garg - Wayne State UniversityAneesha Varrey - Wayne State UniversityAli Alhousseini - Wayne State UniversityRichard Hsu - Wayne State UniversitySonia S. Hassan - Wayne State UniversityEdgar Hernandez-Andrade - The University of Texas at AustinRoberto Romero - Wayne State UniversityMohammad Mehrmohammadi - Wayne State University
- Resource Type
- Conference proceeding
- Publication Details
- 2021 IEEE International Ultrasonics Symposium (IUS), pp.1-4
- Publisher
- IEEE
- DOI
- 10.1109/IUS52206.2021.9593345
- ISSN
- 1948-5719
- eISSN
- 1948-5727
- Grant note
- HHSN275201300006C / U.S. Department of Health and Human Services (DHHS) (10.13039/100000016) National Institute of Child Health and Human Development (NICHD) (10.13039/100000071) 1R01EB030058 / NIBIB (10.13039/100000070) National Institutes of Health (NIH) (10.13039/100000002)
- Language
- English
- Date published
- 09/11/2021
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984359803702771
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