Synchronization Effects in Networks of Striatal Fast Spiking Interneurons - Role of Gap Junctions

Johannes Hjorth; Lennart Hedlund; Kim T Blackwell; Jeanette Hellgren Kotaleski

doi:10.1007/978-1-4020-8387-7_13

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Conference proceeding

Synchronization Effects in Networks of Striatal Fast Spiking Interneurons - Role of Gap Junctions

Johannes Hjorth, Lennart Hedlund, Kim T Blackwell and Jeanette Hellgren Kotaleski

ADVANCES IN COGNITIVE NEURODYNAMICS, PROCEEDINGS, pp.63-66

ADVANCES IN COGNITIVE NEURODYNAMICS, PROCEEDINGS

2008

DOI: 10.1007/978-1-4020-8387-7_13

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Abstract

Recent studies have found gap junctions between striatal fast spiking interneurons (FSN). Gap junctions between neocortical FSNs cause increased synchrony of firing in response to current injection, but the effect of gap junctions in response to synaptic input is unknown. To explore this issue, we built a network model of FSNs. Each FSN connects to 30-40% of its neighbours, as found experimentally, and each FSN in the network is activated by simulated up-state synaptic inputs. Simulation experiments show that the proportion of synchronous spikes in coupled FSNs increases with gap junction conductance. Proximal gap junctions increase the synchronization more than distal gap junctions. During up-states the synchronization effects in FSNs coupled pairwise with proximal gap junctions are small for experimentally estimated gap junction conductances; however, higher order correlations are significantly increased in larger FSN networks.

Computer Science

Information Technology

Natural Sciences

Technology

computational modeling

Computer and Information Sciences

Computer Sciences

Data- och informationsvetenskap

Datalogi

Datavetenskap

Datavetenskap (datalogi)

Fast spiking interneurons

gap junctions

Informationsteknik

Naturvetenskap

striatum

synchronization

TEKNIKVETENSKAP

Details

Title: Subtitle: Synchronization Effects in Networks of Striatal Fast Spiking Interneurons - Role of Gap Junctions
Creators: Johannes Hjorth - AlbaNova
Lennart Hedlund - Skolan för datavetenskap och kommunikation (CSC)
Kim T Blackwell
Jeanette Hellgren Kotaleski - Beräkningsbiologi, CB
Resource Type: Conference proceeding
Publication Details: ADVANCES IN COGNITIVE NEURODYNAMICS, PROCEEDINGS, pp.63-66
Series: ADVANCES IN COGNITIVE NEURODYNAMICS, PROCEEDINGS
DOI: 10.1007/978-1-4020-8387-7_13
Language: English
Date published: 2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
Record Identifier: 9984447847702771

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