Conference proceeding
Temperature and hydration monitoring in tissue-simulating phantoms using novel silicon-photonics-based spectrophotometer
Vol.12375, 1237506
03/06/2023
DOI: 10.1117/12.2649262
Abstract
Consumer adoption of portable and wearable electronic devices is increasing, particularly for monitoring human health and wellness. Current devices rely on a set of established light emitting diodes that are limited in terms of spectral range, resolution, power efficiency, and signal strength, which collectively hinder the ability to quantify a next generation of biomarkers in a wearable format. A novel photonic platform is proposed, whereby analytical information is captured by using a set of silicon-photonics-based III-V semiconductor lasers operating over near infrared wavelengths. A first step in the analytical utility of this photonic platform is assessed by collecting spectroscopic data for a series of gelatin-based tissue-simulating phantoms. Laser-based diffuse reflectance spectra are collected for a set of seven unique phantom matrixes over a range of temperatures from 20-24 °C. In all, 700 spectra are collected and PLS calibration models are developed for the independent measurements of water content and temperature across this array of phantoms. Standard errors of prediction are 0.30 weight-percent for water content measurements and 0.22 °C for phantom temperature. These initial findings support efforts to follow a path from analytical sensing element to a fully integrated non-invasive wearable electronic device.
Details
- Title: Subtitle
- Temperature and hydration monitoring in tissue-simulating phantoms using novel silicon-photonics-based spectrophotometer
- Creators
- Ariel B. Bohman - Rockley PhotonicsJohn Q. Nguyen - Rockley PhotonicsSanjana Parthasarathy - Rockley PhotonicsMark A. Arnold - University of Iowa
- Contributors
- Babak Shadgan (Editor) - International Collaboration On Repair DiscoveriesAmir H. Gandjbakhche (Editor) - Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Resource Type
- Conference proceeding
- Publication Details
- Vol.12375, 1237506
- Publisher
- SPIE
- DOI
- 10.1117/12.2649262
- ISSN
- 1605-7422
- Language
- English
- Date published
- 03/06/2023
- Academic Unit
- Center for Biocatalysis and Bioprocessing; Pharmaceutical Sciences and Experimental Therapeutics; Fraternal Order of Eagles Diabetes Research Center; Chemistry
- Record Identifier
- 9984398344902771
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