Conference proceeding
The Effects of Biaxial Preconditioning on Failure of Acelluluar Collagen Gels
ASME 2010 Summer Bioengineering Conference, Parts A and B, pp.977-978
ASME 2010 Summer Bioengineering Conference, Naples, Florida, USA, Jun. 16 - 19, 2010
06/16/2010
DOI: 10.1115/SBC2010-19384
Abstract
Due to collagen’s importance as an extracellular matrix (ECM) structural protein, it has often been used as a scaffold material for engineered or model tissue [1]. In order to correctly generate new tissues, the scaffolding must mimic the native ECM. The mechanical properties are crucial not only as a structural support but also to allow for cell differentiation [1]. Preconditioning is a processing technique where a sample of soft tissue material is subjected to cyclical strain. As a result, the fibers align in accordance with the direction of preconditioning [2]. Such realignment alters the mechanical properties of the tissue. In order to design more effective tissue engineering scaffolds, it is important to characterize the effects of preconditioning on the damage and failure of collagen constructs. This study attempts to understand how preconditioning alters the stresses, strains, and failure of a sample when it is subjected to a load in different orientations.
Details
- Title: Subtitle
- The Effects of Biaxial Preconditioning on Failure of Acelluluar Collagen Gels
- Creators
- Ryan M Dean - University of MinnesotaEdward A Sander - University of MinnesotaVictor H Barocas - University of Minnesota
- Resource Type
- Conference proceeding
- Publication Details
- ASME 2010 Summer Bioengineering Conference, Parts A and B, pp.977-978
- Conference
- ASME 2010 Summer Bioengineering Conference, Naples, Florida, USA, Jun. 16 - 19, 2010
- DOI
- 10.1115/SBC2010-19384
- Publisher
- American Society of Mechanical Engineers
- Language
- English
- Date published
- 06/16/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984197324702771
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