Conference proceeding
The isolated perfused working mouse heart system
2009 IEEE 35th Annual Northeast Bioengineering Conference, pp.1-2
04/2009
DOI: 10.1109/NEBC.2009.4967760
Abstract
Study of cardioactive agents in vivo is complicated by neurohormonal influences and variations in loading conditions. The working mouse heart perfusion system allows for the ex vivo direct measurement of cardiac metabolism and function, and responses to drugs and hormones, under defined conditions. Myocardial pressure and volume measurements are obtained using a micro-tip catheter inserted into the left ventricular chamber. Direct and derived functional data include heart rate (HR), cardiac output (CO), end systolic pressure (ESP), end diastolic pressure (EDP), end systolic volume (ESV), end diastolic volume (EDV), stroke volume (SV), and ejection fraction (EF). Metabolic data include rates of glycolysis, glucose oxidation, and fatty acid oxidation. The mouse serves as an ideal model for evaluation of the pharmacology and toxicity of novel cardioactive therapeutics due to its rapid reproduction, low cost, and relevance to human physiology.
Details
- Title: Subtitle
- The isolated perfused working mouse heart system
- Creators
- M.E Dunn - University of Rhode IslandA.E Stanhewicz - University of Rhode IslandT.G Manfredi - University of Rhode IslandA.C Cosmas - University of Rhode IslandR.L Rodgers - University of Rhode IslandF.J Vetter - University of Rhode Island
- Resource Type
- Conference proceeding
- Publication Details
- 2009 IEEE 35th Annual Northeast Bioengineering Conference, pp.1-2
- DOI
- 10.1109/NEBC.2009.4967760
- ISSN
- 2160-6986
- eISSN
- 2160-7028
- Publisher
- IEEE
- Language
- English
- Date published
- 04/2009
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259658402771
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