Conference proceeding
Top-down and bottom-up fabrication techniques for hydrogel based sensing and hormone delivery microdevices
Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), Vol.2009, pp.232-235
2009
DOI: 10.1109/IEMBS.2009.5332511
PMID: 19963454
Abstract
We review a set of studies dealing with molecular (glucose) sensing and hormone delivery, in which the swelling and shrinking of a hydrogel as a function of glucose concentration play a central role. Confining hydrogels in microfabricated structures permits transduction of their chemomechanical behaviors. Prototype microdevices for wireless glucose sensing and closed loop insulin delivery control have been designed using hydrogels containing phenylboronic acid sidechains. While these devices exhibit desired responses, improved response time is needed, warranting further miniaturization. In a separate application, geometric confinement of glucose oxidase by a pH-sensitive hydrogel membrane sets up a nonlinear feedback loop which enables rhythmic swell/shrink cycles when the system is exposed to a constant glucose concentration. The latter system may be applied to delivery of gonadotropin release hormone, for which rhythmicity of secretion is essential for therapeutic function.
Details
- Title: Subtitle
- Top-down and bottom-up fabrication techniques for hydrogel based sensing and hormone delivery microdevices
- Creators
- Ronald A Siegel - University of MinnesotaEric E Nuxoll - University of MinnesotaMarc A Hillmyer - University of MinnesotaBabak Ziaie - Purdue University West Lafayette
- Resource Type
- Conference proceeding
- Publication Details
- Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), Vol.2009, pp.232-235
- DOI
- 10.1109/IEMBS.2009.5332511
- PMID
- 19963454
- NLM abbreviation
- Conf Proc IEEE Eng Med Biol Soc
- eISBN
- 9781424432967; 1424432960
- ISSN
- 1557-170X
- eISSN
- 1558-4615
- Grant note
- HD040366 / NICHD NIH HHS HD051366 / NICHD NIH HHS EB003125 / NIBIB NIH HHS DK075739 / NIDDK NIH HHS
- Language
- English
- Date published
- 2009
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemical and Biochemical Engineering
- Record Identifier
- 9984197257402771
Metrics
23 Record Views