Conference proceeding
Towards a miniaturized brain-machine-spinal cord interface (BMSI) for restoration of function after spinal cord injury
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.2014, pp.486-489
08/2014
DOI: 10.1109/EMBC.2014.6943634
PMID: 25570002
Abstract
Nearly 6 million people in the United States are currently living with paralysis in which 23% of the cases are related to spinal cord injury (SCI). Miniaturized closed-loop neural interfaces have the potential for restoring function and mobility lost to debilitating neural injuries such as SCI by leveraging recent advancements in bioelectronics and a better understanding of the processes that underlie functional and anatomical reorganization in an injured nervous system. This paper describes our current progress towards developing a miniaturized brain-machine-spinal cord interface (BMSI) that is envisioned to convert in real time the neural command signals recorded from the brain to electrical stimuli delivered to the spinal cord below the injury level. Specifically, the paper reports on a corticospinal interface integrated circuit (IC) as a core building block for such a BMSI that is capable of low-noise recording of extracellular neural spikes from the cerebral cortex as well as muscle activation using intraspinal microstimulation (ISMS) in a rat with contusion injury to the thoracic spinal cord. The paper further presents results from a neurobiological study conducted in both normal and SCI rats to investigate the effect of various ISMS parameters on movement thresholds in the rat hindlimb. Coupled with proper signal-processing algorithms in the future for the transformation between the cortically recorded data and ISMS parameters, such a BMSI has the potential to facilitate functional recovery after an SCI by re-establishing corticospinal communication channels lost due to the injury.
Details
- Title: Subtitle
- Towards a miniaturized brain-machine-spinal cord interface (BMSI) for restoration of function after spinal cord injury
- Creators
- Shahab Shahdoost - Electr. Eng. & Comput. Sci. Dept., Case Western Reserve Univ., Cleveland, OH, USAShawn Frost - Mol. & Integrative Physiol. Dept., Univ. of Kansas, Kansas City, KS, USAGustaf Van Acker - Mol. & Integrative Physiol. Dept., Univ. of Kansas, Kansas City, KS, USAStacey DeJong - Phys. Therapy & Rehabilitation Sci. Dept., Univ. of Kansas, Kansas City, KS, USACaleb Dunham - Mol. & Integrative Physiol. Dept., Univ. of Kansas, Kansas City, KS, USAScott Barbay - Mol. & Integrative Physiol. Dept., Univ. of Kansas, Kansas City, KS, USARandolph Nudo - Mol. & Integrative Physiol. Dept., Univ. of Kansas, Kansas City, KS, USAPedram Mohseni - Electr. Eng. & Comput. Sci. Dept., Case Western Reserve Univ., Cleveland, OH, USA
- Resource Type
- Conference proceeding
- Publication Details
- 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.2014, pp.486-489
- Publisher
- IEEE
- DOI
- 10.1109/EMBC.2014.6943634
- PMID
- 25570002
- ISSN
- 1094-687X
- eISSN
- 1558-4615
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Physical Therapy and Rehabilitation Science
- Record Identifier
- 9984047689002771
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