Unsupervised Clustering Of Airway Tree Structures On High-Resolution CT: The Mesa Lung Study

Artur Wysoczanski; Elsa D Angelini; Benjamin M Smith; Eric A Hoffman; Grant T Hiura; Yifei Sun; R. Graham Barr; Andrew F Laine

doi:10.1109/ISBI48211.2021.9434172

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Unsupervised Clustering Of Airway Tree Structures On High-Resolution CT: The Mesa Lung Study

Conference proceeding

Open access

Unsupervised Clustering Of Airway Tree Structures On High-Resolution CT: The Mesa Lung Study

Artur Wysoczanski, Elsa D Angelini, Benjamin M Smith, Eric A Hoffman, Grant T Hiura, Yifei Sun, R. Graham Barr and Andrew F Laine

2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), Vol.2021-, pp.1568-1572

04/13/2021

DOI: 10.1109/ISBI48211.2021.9434172

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https://www.ncbi.nlm.nih.gov/pmc/articles/11467910View

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Abstract

The morphology of the proximal human airway tree is highly variable in the general population, and known variants in airway branching patterns are associated with increased risk of COPD and with polymorphisms in growth factors involved in pulmonary development. Variation in the geometry and topology of the airway tree remains incompletely characterized, and their clinical implications are not yet understood. In this work, we present an approach to unsupervised clustering of airway tree structures in Billera-Holmes-Vogtmann tree-space. We validate our pipeline on synthetic airway tree data, and apply our algorithm to identify reproducible and morphologically distinct airway tree subtypes in the MESA Lung CT cohort.

Computed Tomography

Geometry

Morphology

Sociology

Airway Morphology

Clustering algorithms

Community Detection

Computational Anatomy

Lung

Lung CT

Pipelines

Details

Title: Subtitle: Unsupervised Clustering Of Airway Tree Structures On High-Resolution CT: The Mesa Lung Study
Creators: Artur Wysoczanski - Columbia University
Elsa D Angelini - Columbia University
Benjamin M Smith - Columbia University Irving Medical Center
Eric A Hoffman - University of Iowa
Grant T Hiura - Columbia University Medical Center
Yifei Sun - Columbia University
R. Graham Barr - Columbia University Irving Medical Center
Andrew F Laine - Columbia University
Resource Type: Conference proceeding
Publication Details: 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), Vol.2021-, pp.1568-1572
DOI: 10.1109/ISBI48211.2021.9434172
ISSN: 1945-7928
eISSN: 1945-8452
Publisher: IEEE
Grant note: National Center for Advancing Translational Sciences (10.13039/100006108)
Language: English
Date published: 04/13/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318792602771

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