Conference proceeding
Volumetric analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner
Proceedings of SPIE, Vol.5746(1), pp.9-15
Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
04/14/2005
DOI: 10.1117/12.595786
Abstract
The Variable Resolution X-ray (VRX) CT system, developed at the UTHSC, Memphis, has the potential for use in animal imaging. Animal models of tumor progression and pharmacological impact are becoming increasingly important in understanding the molecular and mechanistic basis of tumor development. In general, CT-imaging offers several advantages in animal research: a fast throughput of seconds to minutes reducing the physiological stress animals are exposed to, and it is an inexpensive modality affordable to many animal laboratories. We are developing the VRX CT scanner as a non-invasive imaging modality to measure tumor volume, progression, and metastasis. From the axial images taken by the VRX CT-scanner, tumor area was measured and the tumor volume was calculated. Animals were also imaged using an optical liquid nitrogen-cooled CCD camera to detect tumor fluorescence. A simple image fusion with a planner x-ray image was used to ascertain the position of the tumors, animals were then sacrificed the tumors excised, and the tumor volume calculated by physical measurements. Furthermore, using a specially designed phantom with three spheres of different volumes, we demonstrated that our system allowed us to estimate the volume with up to 10% accuracy; we expect this to increase dramatically in the next few months.
Details
- Title: Subtitle
- Volumetric analysis of tumors in rodents using the variable resolution x-ray (VRX) CT-scanner
- Creators
- M. Waleed Gaber - University of Tennessee Health Science CenterChristy M Wilson - University of Tennessee Health Science CenterChristopher D Duntsch - University of Tennessee Health Science CenterHemant Shukla - University of Tennessee Health Science CenterJanice A Zawaski - University of Tennessee Health Science CenterLawrence M Jordan - University of Tennessee Health Science CenterDavid A Rendon - University of Tennessee Health Science CenterSravanthi Vangalaa - University of Tennessee Health Science CenterGary S Keyes - University of Tennessee Health Science CenterFrank A DiBianca - University of Tennessee Health Science Center
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.5746(1), pp.9-15
- Conference
- Medical Imaging 2005: Physiology, Function, and Structure from Medical Images
- DOI
- 10.1117/12.595786
- ISSN
- 0277-786X
- Number of pages
- 7
- Language
- English
- Date published
- 04/14/2005
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984700456902771
Metrics
1 Record Views