Conference proceeding
White matter degeneration in schizophrenia: a comparative diffusion tensor analysis
Proceedings of SPIE, Vol.7623(1), pp.762329-762328
Medical Imaging 2010: Image Processing
03/05/2010
DOI: 10.1117/12.844283
Abstract
Schizophrenia is a serious and disabling mental disorder. Diffusion tensor imaging (DTI) studies performed on
schizophrenia have demonstrated white matter degeneration either due to loss of myelination or deterioration of fiber
tracts although the areas where the changes occur are variable across studies. Most of the population based studies
analyze the changes in schizophrenia using scalar indices computed from the diffusion tensor such as fractional
anisotropy (FA) and relative anisotropy (RA). The scalar measures may not capture the complete information from the
diffusion tensor. In this paper we have applied the RADTI method on a group of 9 controls and 9 patients with
schizophrenia. The RADTI method converts the tensors to log-Euclidean space where a linear regression model is
applied and hypothesis testing is performed between the control and patient groups. Results show that there is a
significant difference in the anisotropy between patients and controls especially in the parts of forceps minor, superior
corona radiata, anterior limb of internal capsule and genu of corpus callosum. To check if the tensor analysis gives a
better idea of the changes in anisotropy, we compared the results with voxelwise FA analysis as well as voxelwise
geodesic anisotropy (GA) analysis.
Details
- Title: Subtitle
- White matter degeneration in schizophrenia: a comparative diffusion tensor analysis
- Creators
- Madhura A Ingalhalikar - Univ. of Iowa (United States)Nancy C Andreasen - Univ. of Iowa (United States)Jinsuh Kim - Univ. of Iowa (United States)Andrew L Alexander - Univ. of Wisconsin (United States)Vincent A Magnotta - Univ. of Iowa (United States)
- Resource Type
- Conference proceeding
- Publication Details
- Proceedings of SPIE, Vol.7623(1), pp.762329-762328
- Conference
- Medical Imaging 2010: Image Processing
- DOI
- 10.1117/12.844283
- ISSN
- 0277-786X
- Language
- English
- Date published
- 03/05/2010
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984066393302771
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