Lung Anatomy + Particle Deposition (lapd) Mouse Archive

Reinhard R Beichel; Robb W Glenny; Christian Bauer; Melissa A Krueger

doi:10.25820/9arg-9w56

Back

Lung Anatomy + Particle Deposition (lapd) Mouse Archive

Dataset

Open access

Lung Anatomy + Particle Deposition (lapd) Mouse Archive

Reinhard R Beichel, Robb W Glenny, Christian Bauer and Melissa A Krueger

University of Iowa

07/01/2019

DOI: 10.25820/9arg-9w56

Files and links (1)

url

Lung Anatomy + Particle Deposition (lapd) Mouse Archive - Data & Data DescriptionView

CC BY V4.0, Open Access

Abstract

The mouse is the most commonly used animal model for toxicology risk assessments and tobacco smoke exposure. Because it is not possible to study every substance exposure or varying exposure conditions, mathematical models and computer simulations are employed to fill the gap or to extend the range of experimental data. However, computational toxicology is limited in its application to mouse inhalation exposure studies because of the lack of high-resolution accurate airway geometries needed for modeling and site-specific particle deposition data. By combining the unique imaging capabilities of the Imaging Cryomicrotome at the University of Washington with the expertise in highly-automated airway segmentation algorithms from the University of Iowa, we have developed methods to provide high-resolution 3D geometries of the four most commonly studied mice strains along with site-specific airway particle dosimetry in the same animals. All datasets are freely available and can be used to accelerate investigation of health and diseases related to the respiratory system.

Details

Title: Subtitle: Lung Anatomy + Particle Deposition (lapd) Mouse Archive
Creators: Reinhard R Beichel - University of Iowa, Electrical and Computer Engineering
Robb W Glenny - University of Washington
Christian Bauer - University of Iowa, Electrical and Computer Engineering
Melissa A Krueger - University of Washington
Contributors: University of Iowa (Institution)
University of Washington (Institution)
Resource Type: Dataset
Publisher: University of Iowa; Iowa City, Iowa, USA
DOI: 10.25820/9arg-9w56
Grants: Anatomically derived airway models to facilitate computational toxicology in mice, R01ES023863, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date published: 07/01/2019
Description Technical info: All data are stored in commonly utilized file formats for scalar image volumes, volumetric labelmaps, meshes, hierarchical representation of airway centerlines with radii, tables, info files, raw camera images, and structured data.
Academic Unit: Electrical and Computer Engineering; Internal Medicine
Record Identifier: 9983559095702771

Metrics

19 File views/ downloads

419 Record Views