Dataset
Dataset for Structure−Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity
University of Iowa
04/19/2024
DOI: 10.25820/data.007031
Abstract
The concentration-response relationship of three PCB mixtures, namely, A1016, A1254 and the cabinet mixture, and four lower-chlorinated biphenyls were assessed in C6 cells using the MTT cell viability assay. Along with the parent congeners, toxicity of their respective human-relevant metabolites was also similarly assessed in C6 cells. PCB52 and its human-relevant hydroxylated (4-OH-PCB52) and sulfated (4-OH-PCB52 sulfate) metabolites were found to be the most toxic compounds as confirmed via the LDH assay. Further, toxicity of PCB52, 4-OH-PCB52 and 4-OH-PCB52 sulfate was assessed in mouse primary glial cells and rat primary astrocytes and they were found to be similarly toxic in rat primary astrocytes. No sex-dependent differences in toxicity in rat primary astrocytes was observed when assessed by the MTT assay. Further, due to differences in their lipophilicity, partitioning of all the tested PCB congeners and their respective human-relevant metabolites was estimated using the equilibrium partitioning model.
Details
- Title: Subtitle
- Dataset for Structure−Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity
- Creators
- Neha Paranjape - University of IowaLaura E Dean - University of Iowa, Occupational and Environmental HealthAndres Martinez Araneda - University of Iowa, IIHR--Hydroscience and EngineeringJonathan A Doorn - University of Iowa, Medicinal and Natural Products ChemistryRonald B Tjalkens - Colorado State UniversityHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.007031
- Publisher
- University of Iowa
- Grants
- Grant note
- Paranjape was also supported by a Fellowship via the American College of Toxicology.
- Language
- English
- Date collected
- 03/03/2020–10/03/2022
- Date published
- 04/19/2024
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; IIHR--Hydroscience and Engineering; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984580958802771
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