Dataset
Abnormal Development of Cerebellar-Striatal Circuitry in Huntington’s Disease: Supplemental Figures
Dryad
11/21/2020
DOI: 10.5061/dryad.qbzkh18cw
Abstract
Objective: To test the hypothesis that the trajectory of functional
connections over time of the striatum and the cerebellum differs between
pre-symptomatic patients with the HD gene expansion (GE) and patients with
a family history of HD but without the gene-expansion (GNE), we evaluated
function MRI data from the Kids-HD study. Methods: We utilized
resting-state, functional MRI data from participants in the Kids-HD study
between 6 to 18 years old. Participants were divided into the GE (CAG
36-59) and GNE (CAG <36) groups. Seed to seed correlations were
calculated between four regions that provide input signals to the anterior
cerebellum: 1) dorsocaudal putamen; 2) globus pallidus externa; 3)
subthalamic nucleus, and 4) pontine nuclei and two regions that
represented output from the cerebellum, the dentate nucleus to the: 1)
ventrolateral thalamus and 2) dorsocaudal putamen. Linear mixed effects
regression models evaluated differences in developmental trajectories of
these connections over time between groups. Results: Four of the six
striatal-cerebellum correlations showed significantly different
trajectories between groups. All showed a pattern where in the early age
ranges (6-12 years), there was hyperconnectivity in the GE compared to the
GNE with those trajectories showing linear decline in the latter half of
the age range. Conclusion: These results parallel previous findings
showing striatal hypertrophy in GE children as early as age 6. These
findings support the notion of developmentally higher connectivity between
the striatum and cerebellum early in the life of the child with the HD
gene expansion, possibly setting the stage for cerebellar compensatory
mechanisms.
Details
- Title: Subtitle
- Abnormal Development of Cerebellar-Striatal Circuitry in Huntington’s Disease: Supplemental Figures
- Creators
- Jordan Schultz - University of IowaAlexander Tereshchenko - University of IowaJoel Bruss - University of IowaVincent Magnotta - University of Iowa, Iowa Neuroscience InstituteEric Epping - University of IowaPeg Nopoulos - University of Iowa
- Resource Type
- Dataset
- DOI
- 10.5061/dryad.qbzkh18cw
- Publisher
- Dryad
- Grant note
- R01 NS055903 / National Institute of Neurological Disorders and Stroke (https://ror.org/01s5ya894)
- Language
- English
- Date published
- 11/21/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmacy Practice and Science
- Record Identifier
- 9984635128602771
Metrics
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