DIAMOND: The Database of Iowa Animal Models for Ophthalmic and Neurologic Disease. Dataset 2: Slit-lamp images for transgenic mice with the human LOXL1/LOXL1-AS1 locus associated with exfoliation glaucoma.

Michael G Anderson

doi:10.25820/data.007304

Back

Dataset

Open access

DIAMOND: The Database of Iowa Animal Models for Ophthalmic and Neurologic Disease. Dataset 2: Slit-lamp images for transgenic mice with the human LOXL1/LOXL1-AS1 locus associated with exfoliation glaucoma.

Michael G Anderson

University of Iowa

07/30/2024

DOI: 10.25820/data.007304

Files and links (4)

txt

Diamond2_Readme6.63 kBDownload View

READMEData creator, data source, funding, file organization, methods.Open Data Commons Attribution (ODC-By) V1.0, Open Access

csv

Data_Dictionary631.00 byteDownload View

Data DictionaryOpen Data Commons Attribution (ODC-By) V1.0, Open Access

csv

Mouse_Exam_Inventory3.42 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

url

Link to Globus for downloading data filesView

Data files are accessible via this link to Globus. Download from Globus via web browser, or Globus app.Open Data Commons Attribution (ODC-By) V1.0, Open Access

Abstract

The following dataset is a collection of slit-lamp photographs of mice in which 166 kb of human genomic DNA from the 15q24.1 locus (BAC RP11-71M11) was introduced into the mouse genome via BAC transgenes. Exfoliation syndrome (XFS) is a systemic disease of elastin-rich tissues involving a deposition of fibrillar exfoliative material (XFM) in the anterior chamber of the eye, which can promote glaucoma. The purpose of this study was to screen the RP11-71M11 transgenics for indices of XFS. Mice were phenotyped by slit-lamp imaging at 1–5 mos of age. Smaller cohorts of 12-mos-old mice were also studied.

Exfoliative glaucoma

Pseudoexfoliation syndrome

Iris

Cornea

Anterior chamber

Glaucoma genetics

GWAS genetics

Details

Title: Subtitle: DIAMOND: The Database of Iowa Animal Models for Ophthalmic and Neurologic Disease. Dataset 2: Slit-lamp images for transgenic mice with the human LOXL1/LOXL1-AS1 locus associated with exfoliation glaucoma.
Creators: Michael G Anderson - University of Iowa, Molecular Physiology and Biophysics
Contributors: Brian Westra (Contributor) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
Publisher: University of Iowa
DOI: 10.25820/data.007304
Grants: CRISPR/Cas9 approaches to model exfoliation syndrome, R21EY029991, National Institutes of Health (United States, Bethesda) - NIH
Multidisciplinary Investigations in Visual Science, P30EY025580, National Institutes of Health (United States, Bethesda) - NIH
Foundational Biology of Glaucoma GWAS Loci, R01EY035679, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 11/2019 - 11/2020
Date published: 07/30/2024
Academic Unit: Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences; Humanities and Social Sciences/Scholarly Impact
Record Identifier: 9984656031502771

Metrics

2 File views/ downloads

15 Record Views