Dataset
Data from: Developmental exposure to a human-relevant PCB mixture: Impacts on PCB congeners, metabolites, and drug-metabolizing enzymes in the bladder of post-weaning mice
Dryad
05/18/2026
DOI: 10.5061/dryad.gxd25482c
Abstract
This dataset includes data from a study investigating how developmental exposure to an environmental PCB mixture, the MARBLES mix, affects post-weaning dam mice bladder. The MARBLES mix mimics the relative composition of the 12 most abundant PCB congeners identified in the serum of pregnant women at higher risk of having a child with a neurodevelopmental disorder. Female dam mice were dosed with MARBLES mix (vehicle, 0.1, 1, or 6 mg/kg/day) via diet two weeks before mating with a male, and dosing continued through mating, gestation, and lactation until collection (67 ± 10 days dosed). PCBs and hydroxylated PCBs (OH-PCBs) levels were quantified in bladder, liver, blood, adipose, and urine. Cytochrome P450 (CYP) expression was measured in bladder and liver. This dataset provides each PCB and OH-PCB concentration in different tissue types, as well as the quality assurance and quality control (QA/QC) results. CYP expressions in bladder and liver were also reported in the dataset.
Details
- Title: Subtitle
- Data from: Developmental exposure to a human-relevant PCB mixture: Impacts on PCB congeners, metabolites, and drug-metabolizing enzymes in the bladder of post-weaning mice
- Creators
- Hui Wang - University of IowaAlex Goskowicz - University of Wisconsin–MadisonAudrey Spiegelhoff - University of Wisconsin–MadisonConner Kennedy - University of Wisconsin–MadisonMonica Ridlon - University of Wisconsin–MadisonRachel Marek - University of IowaHans-Joachim Lehmler - University of IowaKimberly Keil Stietz - University of Wisconsin–Madison
- Resource Type
- Dataset
- DOI
- 10.5061/dryad.gxd25482c
- Publisher
- Dryad
- Grant note
- Molecular & Environmental Toxicology Predoctoral Training Program - 2T32ES007015-46A1 / National Institute of Environmental Health Sciences (https://ror.org/00j4k1h63) PCB induced neurogenic inflammation mediates bladder dysfunction - 5R00ES029537-05 / National Institute of Environmental Health Sciences (https://ror.org/00j4k1h63) Environmental Health Sciences Research Center - 5P30ES005605-35 / National Institute of Environmental Health Sciences (https://ror.org/00j4k1h63) Impact of developmental polychlorinated biphenyls on bladder contractility - 5R01ES035020-02 / National Institute of Environmental Health Sciences (https://ror.org/00j4k1h63) Analytical Core - 5P42ES013661-21 / National Institute of Environmental Health Sciences (https://ror.org/00j4k1h63) Role of estrogen receptor beta in polychlorinated biphenyls impacts on bladder function - 1F31ES036876-01A1 / National Institute of Environmental Health Sciences (https://ror.org/00j4k1h63)
- Language
- English
- Date published
- 05/18/2026
- Academic Unit
- Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; IIHR--Hydroscience and Engineering
- Record Identifier
- 9985183560202771
Metrics
1 Record Views