Dataset
Data from: Sensing, feeling, and regulating: Investigating the association of focal brain damage with voluntary respiratory and motor control
Dryad
10/04/2024
DOI: 10.5061/dryad.z08kprrkg
Abstract
Breathing is a complex, vital function that can be modulated to influence physical and mental well-being. However, the role of cortical and subcortical brain regions in voluntary control of human respiration is underexplored. Here we investigated the influence of damage to human frontal, temporal, or limbic regions on the sensation and regulation of breathing patterns. Participants performed a respiratory regulation task across regular and irregular frequencies ranging from 6 to 60 breaths per minute (bpm), with a counterbalanced hand motor control task. Interoceptive and affective states induced by each condition were assessed via questionnaire and autonomic signals were indexed via skin conductance. Participants with focal lesions to the bilateral frontal lobe, right insula/basal ganglia, and left medial temporal lobe demonstrated significantly lower performance than individually matched healthy comparisons during the breathing and motor tasks. They also reported significantly higher anxiety during the 60-bpm regular and irregular breathing trials than healthy participants. Correlations between task performance, anxiety, and difficulty varied across experimental conditions and groups. This study demonstrates that damage to frontal, temporal, or limbic regions is associated with abnormal voluntary respiratory and motor regulation and tachypnea-related anxiety, highlighting the role of the forebrain in affective and motor responses during breathing.
Details
- Title: Subtitle
- Data from: Sensing, feeling, and regulating: Investigating the association of focal brain damage with voluntary respiratory and motor control
- Creators
- Henrik Bischoff - Stockholm UniversityChristopher Kovach - University of IowaSukbhinder Kumar - University of IowaJoel Bruss - University of IowaDaniel Tranel - University of IowaSahib S. Khalsa - Laureate Institute for Brain Research
- Resource Type
- Dataset
- DOI
- 10.5061/dryad.z08kprrkg
- Publisher
- Dryad
- Grant note
- F31AT003061 / National Center for Complementary and Integrative Health (https://ror.org/00190t495) Kiwanis International Neuroscience Research Foundation
- Language
- English
- Date published
- 10/04/2024
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984722715402771
Metrics
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