Dataset: Fatty Liver and Impaired Hepatic Metabolism Alter the Congener-specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with A Liver-specific Deletion of Cytochrome P450 Reductase

Xueshu Li; Chunyun Zhang; Kai Wang; Hans-Joachim Lehmler

doi:10.25820/data.006117

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Dataset: Fatty Liver and Impaired Hepatic Metabolism Alter the Congener-specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with A Liver-specific Deletion of Cytochrome P450 Reductase

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Dataset: Fatty Liver and Impaired Hepatic Metabolism Alter the Congener-specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with A Liver-specific Deletion of Cytochrome P450 Reductase

Xueshu Li, Chunyun Zhang, Kai Wang and Hans-Joachim Lehmler

University of Iowa

07/20/2020

DOI: 10.25820/data.006117

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txt

Readme_DistributionOfAroclor1254InMice10.06 kBDownload View

README Open Access CC BY V4.0

xlsx

Dataset_DistributionOfAroclor1254InMice924.74 kBDownload View

Open Access CC BY V4.0

csv

SubstanceIdentifiers17.64 kBDownload View

This table contains computed descriptors (identifiers) and database identifiers for chemical substances that are represented in this dataset. The identifiers include the internal (ISRP) name and ID, and may include the following if available: CAS number, DSSTox substance ID, InChl Key, IUPAC name, PubChem CID and Canonical SMILES ID. Open Access CC BY V4.0

Abstract

This excel data sheet summarizes quality assurance /quality control (QA/QC) data, including method detection limits (MDL), recovery rates of spiked ongoing precision and recovery standards (OPR) in both blank solvent and tissue matrix, limits of detection in both mass (ng) and concentration (ng/g tissue) from a study investigating the congener specific tissue distribution in mice exposed orally to Aroclor 1254. In addition, data from individual animals are tabulated for PCB homolog group, PCB Class, or individual levels congeners, as appropriate.

Arochlor 1254

cytochrome p450 reductase

mice

tissue distribution

PCB

Synthesis Core

Analytical Core

Details

Title: Subtitle: Dataset: Fatty Liver and Impaired Hepatic Metabolism Alter the Congener-specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with A Liver-specific Deletion of Cytochrome P450 Reductase
Creators: Xueshu Li - University of Iowa, Occupational and Environmental Health
Chunyun Zhang - University of Iowa, Occupational and Environmental Health
Kai Wang - University of Iowa, Biostatistics
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Resource Type: Dataset
Resource Sub-type: Data
DOI: 10.25820/data.006117
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB Enantiomers Implicated in Neurodevelopmental Disorders: Identification of Individual Metabolic Factors that Determine Risk and Vulnerability, R21ES027169, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date published: 07/20/2020
Description methods: Methods and other information about the dataset are provided in the readme file.
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute; Biostatistics; Iowa Superfund Research Program
Record Identifier: 9983778800302771

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Dataset: Fatty Liver and Impaired Hepatic Metabolism Alter the Congener-specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with A Liver-specific Deletion of Cytochrome P450 Reductase

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