Dataset: Polymeric Implant to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol in Male Rats

Hui Wang; Amanda J Bullert; Xueshu Li; Hanna E Stevens; Aloysius J Klingelhutz; James A Ankrum; Andrea Adamcakova-Dodd; Peter S Thorne; Hans-Joachim Lehmler

doi:10.25820/data.006796

Back

Dataset

Open access

Dataset: Polymeric Implant to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol in Male Rats

Hui Wang, Amanda J Bullert, Xueshu Li, Hanna E Stevens, Aloysius J Klingelhutz, James A Ankrum, Andrea Adamcakova-Dodd, Peter S Thorne and Hans-Joachim Lehmler

University of Iowa

11/02/2023

DOI: 10.25820/data.006796

Files and links (18)

txt

Readme13.54 kBDownload View

READMEIncludes creators, abstract, data and file overview, abbreviations and nomenclature, and methods.Open Data Commons Attribution (ODC-By) V1.0, Open Access

txt

Readme_pathology_scoring_parameters2.77 kBDownload View

READMEPathology scoring parameters used for evaluating the image files in D12_Histopathology_images (folder)Open Data Commons Attribution (ODC-By) V1.0, Open Access

csv

data_dictionary16.25 kBDownload View

Data DictionaryData dictionary for the data tables in the dataset (D1 - D11, D13 - D15).Open Data Commons Attribution (ODC-By) V1.0, Open Access

csv

D1_In_vitro_release_in_mass_at_each_timepoint2.01 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

csv

D2_In_vitro_daily_and_cumulative_release_in_percentage3.63 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

Abstract

This dataset summarized a study of investigating the subacute neurotoxicity of a human-relevant metabolite, 2,2',5,5'-tetrachlorobiphenyl-4-ol (4-52), on male adolescent Sprague Dawley rats, via a novel polymeric implant drug delivery system grafted subcutaneously, at total loading concentrations ranging from 0, 1, 5, and 10% of the implant (w/w) for 28 days. 4-52 and other possible hydroxylated metabolites in serum and vital tissues were quantified using gas chromatography with tandem mass spectrometry (GC-MS/MS). The dataset contains 4-52 concentration in mass (ug) and percentage (%) in medium from in vitro release experiment, mass (ng) and concentration (ng/g tissue) of 4-52 and its metabolites in serum, lung, brain and liver, the body weight and tissue weight, the neurobehavioral testing data, the histopathology evaluation and images, and the QA/QC data.

Details

Title: Subtitle: Dataset: Polymeric Implant to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol in Male Rats
Creators: Hui Wang - University of Iowa, Occupational and Environmental Health
Amanda J Bullert - University of Iowa
Xueshu Li - University of Iowa, Occupational and Environmental Health
Hanna E Stevens - University of Iowa, Iowa Neuroscience Institute
Aloysius J Klingelhutz - University of Iowa, Microbiology and Immunology
James A Ankrum - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
Andrea Adamcakova-Dodd - University of Iowa, Occupational and Environmental Health
Peter S Thorne - University of Iowa, Civil and Environmental Engineering
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Resource Type: Dataset
DOI: 10.25820/data.006796
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 08/15/2022–05/23/2023
Date published: 11/02/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Civil and Environmental Engineering; Microbiology and Immunology; Occupational and Environmental Health; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program
Record Identifier: 9984473228602771

Metrics

8 File views/ downloads

125 Record Views