Dataset
Dataset for 3,3'-Dichlorobiphenyl (PCB 11) Alters the Hepatic Expression of Cytochrome P450 Enzymes in the Liver of Mouse Dams Exposed Orally During Pregnancy and Lactation.
University of Iowa
11/21/2025
DOI: 10.25820/data.007803
Abstract
As part of a larger study on neurodevelopmental effects of lower‑chlorinated PCB 11, we characterized PCB 11 distribution in postweaning mouse dams orally exposed to PCB 11 via the diet. We used liquid chromatography mass spectrometry-tandem mass spectrometry (LC‑MS/MS) to map global changes in hepatic protein levels, gas chromatography mass spectrometry-tandem mass spectrometry (GC‑MS/MS) to quantify PCB 11 and its metabolites in brain, liver, and serum; and liquid chromatography-high resolution mass spectrometry (LC-HRMS) to screen serum for additional PCB 11 metabolites. The accompanying dataset contains raw and processed files from the GC-MS/MS and LC-HRMS, including PCB 11 and associated metabolite concentrations, detection limits, recoveries, and chromatogram peak areas. The LC-MS/MS proteomics dataset is publicly available through the University of California, San Diego’s Center for Computational Mass Spectrometry MassIVE Repository (MSV000099827) and ProteomeXchange Consortium (PXD070556) under the DOI: https://doi.org/10.25345/C56W96P25.
Details
- Title: Subtitle
- Dataset for 3,3'-Dichlorobiphenyl (PCB 11) Alters the Hepatic Expression of Cytochrome P450 Enzymes in the Liver of Mouse Dams Exposed Orally During Pregnancy and Lactation.
- Creators
- Crystal M Roach - University of Iowa, Occupational and Environmental HealthNate R. Koester - University of IowaXueshu Li - University of Iowa, Occupational and Environmental HealthJeonghyeon Ahn - University of Iowa, Occupational and Environmental HealthR Marshall Pope - University of Iowa, Medicine AdministrationRebecca J. Wilson - University of California, DavisRosalia Mendieta - University of California, DavisAnthony E Valenzuela - University of California, DavisWeiguo Han - University of ArizonaXinxin Ding - University of ArizonaPamela J Lein - University of California, DavisHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.007803
- Publisher
- University of Iowa
- Grants
- Language
- English
- Date collected
- 12/24/2023–01/31/2025
- Date published
- 11/21/2025
- Academic Unit
- Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program; Medicine Administration
- Record Identifier
- 9984831010302771
Metrics
9 File views/ downloads
52 Record Views