Dataset for Cytochrome P450 Expression Influences Behavioral Responses to Gestational and Lactational Exposure to Polychlorinated Biphenyl (PCB) 11 in Juvenile Male and Female Mice

Crystal M Roach; Rebecca J. Wilson; Rosalia Mendieta; Anthony E Valenzuela; Yi-Hua Tsai; Xueshu Li; Xinxin Ding; Hans-Joachim Lehmler; Pamela J Lein

doi:10.25820/data.008279

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Dataset for Cytochrome P450 Expression Influences Behavioral Responses to Gestational and Lactational Exposure to Polychlorinated Biphenyl (PCB) 11 in Juvenile Male and Female Mice

Crystal M Roach, Rebecca J. Wilson, Rosalia Mendieta, Anthony E Valenzuela, Yi-Hua Tsai, Xueshu Li, Xinxin Ding, Hans-Joachim Lehmler and Pamela J Lein

University of Iowa

07/08/2026

DOI: 10.25820/data.008279

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0_Readme_IRO_PCB 11_Pups_Roach16.17 kBDownload View

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1_data_dictionary_targeted_untargeted2.30 kBDownload View

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2_dataset_labels_targeted4.68 kBDownload View

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3_dataset_labels_untargeted2.63 kBDownload View

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4_substance_descriptors_and_identifiers6.52 kBDownload View

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Abstract

As part of a larger study on neurodevelopmental effects of lower‑chlorinated PCB 11, we quantified PCB 11 and metabolites in postnatal day (P)21 and P35 mouse pup serum exposed orally to PCB 11 via the maternal diet. We used gas chromatography mass spectrometry-tandem mass spectrometry (GC‑MS/MS) to quantify PCB 11 and liquid chromatography-high resolution mass spectrometry (LC-HRMS) to screen for additional PCB 11 metabolites. The accompanying dataset contains raw and processed files from the GC-MS/MS and LC-HRMS, including PCB 11 and associated metabolite concentrations, detection limits, recoveries, and chromatogram peak areas.

Neurotoxicology

Mice

PCB 11

Cytochrome P450 Expression

Gestational exposure

Lactational exposure

Details

Title: Subtitle: Dataset for Cytochrome P450 Expression Influences Behavioral Responses to Gestational and Lactational Exposure to Polychlorinated Biphenyl (PCB) 11 in Juvenile Male and Female Mice
Creators: Crystal M Roach - University of Iowa, Occupational and Environmental Health
Rebecca J. Wilson - University of California, Davis
Rosalia Mendieta - University of California, Davis
Anthony E Valenzuela - University of California, Davis
Yi-Hua Tsai - University of California, Davis
Xueshu Li - University of Iowa, Occupational and Environmental Health
Xinxin Ding - University of Arizona
Hans-Joachim Lehmler - University of Iowa, Iowa Neuroscience Institute
Pamela J Lein - University of California, Davis
Contributors: Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.008279
Publisher: University of Iowa
Grants: PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
Initiative for Maximizing Student Development at the University of California, Davis., 5T32GM135741, National Institute of General Medical Sciences (United States, Bethesda) - NIGMS
Environmental Toxicology, T32ES007059, National Institute of Environmental Health Sciences (United States, Durham) - NIEHS
Grant note: This work was supported by the National Institute of Environmental Health [grant numbers R01 ES014901 and R01 ES031098]. Dr. Rebecca J Wilson was supported in part by the UC Davis Emmy Werner and Stanley Jacobsen Fellowship and the UC Davis Professors for the Future Fellowship Program. Rosalia Mendieta was supported by NIH-funded training grants (T32 GM135741 and T32 ES007059). The contents of this study do not necessarily represent the official views of the NIH, and the NIH does not endorse the purchase of any commercial products or services mentioned in the publication.
Language: English
Date collected: 01/17/2024–01/31/2026
Date published: 07/08/2026
Academic Unit: Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact
Record Identifier: 9985174012402771

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