Dataset for: Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture.

Dataset

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Dataset for: Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture.

Laura E Dean, Hui Wang, Xueshu Li, Rachel L Fitzjerrells, Anthony E Valenzuela, Kari Neier, Janine M LaSalle and Hans-Joachim Lehmler

University of Iowa

03/12/2025

DOI: 10.25820/data.007461

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README_MARBLES_Microbiome22.83 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

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ChemicalSubstance_Identifiers5.26 kBDownload View

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data_dictionary7.19 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

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01_ASV_Table25.36 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

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02_MARBLES_0.1_KEGG_enrichment11.01 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

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Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associate...

Abstract

This dataset includes the data from a study investigating how an environmental PCB mixture, the MARBLES mix, affects microbial communities. The MARBLES mix mimics the relative composition of the 12 most abundant PCB congeners identified in the serum of pregnant women at higher risk of having a child with a neurodevelopmental disorder. Hybrid 75% C57Bl/6J/25% SVJ129 mice were exposed daily for 7 weeks to peanut butter containing either a sham dose (0 mg/kg/day) or low (0.1 mg/kg/day), medium (1 mg/kg/day), or high (6 mg/kg/day) doses of PCBs. About 20 hours after the final exposure, microbiome composition and PCB metabolite levels were analyzed in the cecal content, and PCB and OH-PCB levels were analyzed in discarded feces.

Metabolites

Neurotoxicology

Toxicology

Polychlorinated biphenyls

Neurodevelopmental disorder

Mice

Microbiome

OH-PCBs

PCBs

Details

Title: Subtitle: Dataset for: Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture.
Creators: Laura E Dean - University of Iowa, Occupational and Environmental Health
Hui Wang - University of Iowa, Occupational and Environmental Health
Xueshu Li - University of Iowa, Occupational and Environmental Health
Rachel L Fitzjerrells
Anthony E Valenzuela - University of California, Davis
Kari Neier - University of California Davis Medical Center
Janine M LaSalle - University of California, Davis
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Resource Type: Dataset
DOI: 10.25820/data.007461
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES), R01ES029213, National Institutes of Health (United States, Bethesda) - NIH
UC Davis Environmental Health Sciences Core Center, P30ES023513, National Institutes of Health (United States, Bethesda) - NIH
The oral microbiome as a window into the pathobiology of multiple sclerosis, leading to new ideas for personalized microbial therapies, F31DE033564, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 01/01/2019–10/31/2024
Date published: 03/12/2025
Academic Unit: Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
Record Identifier: 9984756175802771

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