Dataset for Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum

Hui Wang; Amanda J Bullert; Morgan J. Linahon; Michael E Dailey; Jonathan A Doorn; Aloysius J Klingelhutz; Hans-Joachim Lehmler

doi:10.25820/data.007551

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Dataset for Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum

Hui Wang, Amanda J Bullert, Morgan J. Linahon, Michael E Dailey, Jonathan A Doorn, Aloysius J Klingelhutz and Hans-Joachim Lehmler

University of Iowa

03/27/2025

DOI: 10.25820/data.007551

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Readme17.47 kBDownload View

READMEInformation about the dataset, including data creators, license, abstract, file list and descriptions, and methods.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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data_dictionary9.96 kBDownload View

Data DictionaryDescriptions and information about variable names and column headings in the data files.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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D1_Metabolomics in Serum_Implant295.65 kBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

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D2_Male_STN_counts1.55 MBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

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D3_Male_CRBLM_counts1.57 MBDownload View

Open Data Commons Attribution (ODC-By) V1.0, Open Access

Abstract

This dataset includes the data for a study investigating the neurotoxicity of a human-relevant metabolite, 2,2',5,5'-tetrachlorobiphenyl-4-ol (4-52), in male adolescent Sprague Dawley rats following a 28-day exposure via a novel polymeric implant delivery system grafted subcutaneously. The total 4-52 loading concentrations of the implants were 0, 1, 5, and 10% by weight. The dataset provides bulk RNA sequencing results, including the count table for each gene and differentially expressed genes (DEGs) in the striatum and cerebellum, the metabolomics results in the serum, dopamine and metabolites levels in the striatum, and 4-52 and metabolites levels in the serum and brain.

Dopamine

Polychlorinated biphenyls

PCBs

polymeric implant

Neurotoxicity

Transcriptomics

RNA Sequencing

Metabolomics

Network Analysis

Details

Title: Subtitle: Dataset for Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum
Creators: Hui Wang - University of Iowa, Occupational and Environmental Health
Amanda J Bullert
Morgan J. Linahon - University of Iowa
Michael E Dailey - University of Iowa, Iowa Neuroscience Institute
Jonathan A Doorn - University of Iowa, Medicinal and Natural Products Chemistry
Aloysius J Klingelhutz - University of Iowa, Microbiology and Immunology
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Contributors: Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.007551
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 08/15/2022–12/31/2024
Date published: 03/27/2025
Academic Unit: Public Health Administration; Microbiology and Immunology; Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Biology; Radiation Oncology; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
Record Identifier: 9984797673102771

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Dataset for Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum

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