Dataset
Dataset for: The bladder as a target for PCB toxicity: Evidence from PCB levels, phase I metabolite levels, and cytochrome P450 expression following developmental exposure to a human-relevant PCB mixture in mice
University of Iowa
02/12/2026
DOI: 10.25820/data.008178
Abstract
This dataset includes data from a study investigating how developmental exposure to an environmental PCB mixture, the MARBLES mix, affects mice bladder. The MARBLES mix mimics the relative composition of the 12 most abundant PCB congeners identified in the serum of pregnant women at higher risk of having a child with a neurodevelopmental disorder. We exposed mice MARBLES mix via maternal diet during gestation and lactation (vehicle, 0.1, 1, or 6 mg/kg/day). Offspring were euthanized at 6 to 7 weeks of age. PCBs and hydroxylated PCBs (OH-PCBs) levels were quantified in bladder, liver, blood, and urine. Cytochrome P450 (CYP) expression was measured in bladder and liver. This dataset provides each PCB and OH-PCB concentration in different tissue types, as well as the quality assurance and quality control (QA/QC) results. CYP expressions in bladder and liver were also reported in the dataset.
Details
- Title: Subtitle
- Dataset for: The bladder as a target for PCB toxicity: Evidence from PCB levels, phase I metabolite levels, and cytochrome P450 expression following developmental exposure to a human-relevant PCB mixture in mice
- Creators
- Hui Wang - University of Iowa, Occupational and Environmental HealthElaine A Schumacher - University of Wisconsin–MadisonAudrey Spiegelhoff - University of Wisconsin–MadisonConnor L. Kennedy - University of Wisconsin–MadisonMonica M. Ridlon - University of Wisconsin–MadisonRachel F Marek - University of Iowa, IIHR--Hydroscience and EngineeringKimberly P Keil Stietz - University of Wisconsin–MadisonHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.008178
- Publisher
- University of Iowa
- Grants
- Language
- English
- Date collected
- 10/09/2018–08/01/2025
- Date published
- 02/12/2026
- Academic Unit
- Public Health Administration; Occupational and Environmental Health; IIHR--Hydroscience and Engineering; Humanities and Social Sciences/Scholarly Impact
- Record Identifier
- 9985096223002771
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