Dataset
Dataset for: The influence of an environmentally relevant polychlorinated biphenyl mixture on the intestinal microbiota in post-weaning mouse dams.
University of Iowa
12/18/2025
DOI: 10.25820/data.007799
Abstract
This dataset comprises data from a study examining the effect of maternal exposure to a human-relevant PCB mixture, known as the MARBLES mix, on the gut microbiome of pregnant female mice. Female C57BL/6J mice were dosed daily with the MARBLES mix at varying concentrations (0, 0.1, 1, or 6 mg/kg body weight/day) before mating and throughout gestation and lactation. Intestinal contents were collected to characterize the microbiome composition and predict its function using 16S rRNA sequencing. Additionally, the quantification of PCBs and their metabolites was performed using gas chromatography-tandem mass spectrometry (GC-MS/MS) and liquid chromatography-high resolution mass spectrometry (LC-HRMS). An interactive network analysis was conducted to identify associations between specific PCBs and metabolites and changes in bacterial abundance.
Details
- Title: Subtitle
- Dataset for: The influence of an environmentally relevant polychlorinated biphenyl mixture on the intestinal microbiota in post-weaning mouse dams.
- Creators
- Hui Wang - University of Iowa, Occupational and Environmental HealthLaura E Dean - University of Iowa, Occupational and Environmental HealthXueshu Li - University of Iowa, Occupational and Environmental HealthRachel L Shrode - University of IowaKai Wang - University of Iowa, BiostatisticsAshutosh K Mangalam - University of Iowa, Iowa Neuroscience InstituteRachel F Marek - University of Iowa, IIHR--Hydroscience and EngineeringConner L. Kennedy - University of Wisconsin–MadisonMonica M. Ridlon - University of Wisconsin–MadisonAudrey Spiegelhoff - University of Wisconsin–MadisonKimberly P Keil Stietz - University of California, DavisHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.007799
- Publisher
- University of Iowa
- Grants
- Comment
- 16S data raw fastq files from the microbiome analysis are deposited on SRA under the BioProject ID PRJNA1272122. Data is released on July 1, 2026.
- Language
- English
- Date collected
- 10/09/2018–06/01/2025
- Date published
- 12/18/2025
- Academic Unit
- Public Health Administration; Occupational and Environmental Health; Pathology; Iowa Neuroscience Institute; Biostatistics; IIHR--Hydroscience and Engineering; Humanities and Social Sciences/Scholarly Impact
- Record Identifier
- 9984827935702771
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