Dataset
Dataset for the Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2’,5,5’-Tetrachlorobiphenyl) on the Brain Transcriptome
University of Iowa
10/08/2024
DOI: 10.25820/data.006801
Abstract
This dataset includes the data from a study investigating the effects of inhaled PCB52 on the adolescent brain. This study used adolescent Sprague-Dawley rats to determine the neurological effects of a subacute (28-day) PCB52 inhalation exposure. Rats were exposed 4 h a day for 28 consecutive days with neurobehavioral tests conducted during the last 5 days of exposure. Based on the data including body weight and tissue weights, PCB52 and metabolite levels (target and non-target analyses), gene expression in the striatum and cerebellum, and neurobehavioral tests [Y-maze, hole board test (HBT), open field test (OFT), and elevated plus maze (EPM)], brain immunohistochemistry images; a subacute inhalation of PCB52 results in multilevel effects of inhaled PCB52 on the rat brain, from gene expression to behavioral effects.
Details
- Title: Subtitle
- Dataset for the Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2’,5,5’-Tetrachlorobiphenyl) on the Brain Transcriptome
- Creators
- Amanda J Bullert - University of IowaHui Wang - University of Iowa, Occupational and Environmental HealthMorgan J. Linahon - University of IowaMichael S Chimenti - University of Iowa, Iowa Institute of Human GeneticsAndrea Adamcakova-Dodd - University of Iowa, Occupational and Environmental HealthXueshu Li - University of Iowa, Occupational and Environmental HealthMichael E Dailey - University of Iowa, Iowa Neuroscience InstituteAloysius J Klingelhutz - University of Iowa, Microbiology and ImmunologyJames A Ankrum - University of Iowa, Fraternal Order of Eagles Diabetes Research CenterHanna E Stevens - University of Iowa, Iowa Neuroscience InstitutePeter S Thorne - University of Iowa, Civil and Environmental EngineeringHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Contributor) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.006801
- Publisher
- University of Iowa
- Grants
- Language
- English
- Date collected
- 03/17/2022–12/31/2023
- Date published
- 10/08/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Civil and Environmental Engineering; Microbiology and Immunology; Occupational and Environmental Health; Iowa Neuroscience Institute; Biology; Radiation Oncology; Humanities and Social Sciences/Scholarly Impact; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program; Iowa Institute of Human Genetics
- Record Identifier
- 9984517357802771
Metrics
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