Datasets for Germ-free Status but Not Subacute Polychlorinated Biphenyl  (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice

Xueshu Li; Hui Wang; Amanda J Bullert; Julia Yue Cui; Kai Wang; Hans-Joachim Lehmler

doi:10.25820/data.006915

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Datasets for Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice

Xueshu Li, Hui Wang, Hui Wang, Amanda J Bullert, Julia Yue Cui, Kai Wang and Hans-Joachim Lehmler

University of Iowa

04/01/2024

DOI: 10.25820/data.006915

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Readme_Hepatic lipidomics11.51 kBDownload View

READMEData set creators, funding, license, abstract, file list and descriptions, abbreviations and nomenclature, methods, and references.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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Data_dictionary1.27 kBDownload View

Data DictionaryThis file contains sample identifiers, inlcuding running #, sample ID1, sample sequencial number, and sample ID2.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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SubstanceIdentifiers686.00 byteDownload View

A table providing computed and database identifiers (CAS Registry Number, DSSTox Substance ID, InChI Key, IUPAC Name, PubChem CID, and Canonical SMILES) for PCB 11, PCB 77, PCB 126, and PCB 153.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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D1_PL_nmol-p-mg-protein28.05 kBDownload View

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D2_FA_nmol-p-mg-protein29.95 kBDownload View

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Abstract

This dataset includes lipidomic analyses from a study investigating the toxicity of the Fox River Mixture (FRM), an environmental polychlorinated biphenyl (PCB) mixture, in adult conventional and germ-free mice (Cheng et al., 2018; Li et al., 2022; Lim et al., 2020). The mice were exposed orally once daily for 3 consecutive days to the FRM at a low dose (6 mg per kg body weight) and a high dose (30 mg per kg body weight). The control group was exposed to the vehicle (corn oil) alone. This dataset includes polar lipids, fatty acids incorporated into triacylglycerides, and triacylglyceride levels, expressed as signal per milligram protein. The original analytical data and LC-MS spectra of both polar lipids and TAG are also included as compressed Excel files. In addition, the extractable lipid content is reported for the lung, brain, jejunum, duodenum, ileum, stomach, cecum, colon, muscle, kidney, liver, and heart from naïve conventional and germ-free mice. These tissues were generated as part of published animal studies(Fu et al., 2021; Selwyn et al., 2015).

Lipidomics

Polychlorinated Biphenyls

PCB

Germ-free mice

Triacylglycerides

Polar lipids

Conventional mice

Details

Title: Subtitle: Datasets for Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice
Creators: Xueshu Li - University of Iowa, Occupational and Environmental Health
Hui Wang - University of Iowa, Occupational and Environmental Health
Hui Wang - University of Iowa, Occupational and Environmental Health
Amanda J Bullert - University of Iowa, Occupational and Environmental Health
Julia Yue Cui - University of Washington
Kai Wang - Institute for Systems Biology
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Contributors: Brian Westra (Contributor) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.006915
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
Developmental Regulation of Drug Processing Genes, R01ES019487, National Institutes of Health (United States, Bethesda) - NIH
Epigenetic Regulation of Drug Metabolism by Developmental Exposure to PBDEs, R01ES025708, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome, R01GM111381, National Institutes of Health (United States, Bethesda) - NIH
University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment, P30ES007033, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
MRI: Acquisition of an electrospray ionization triple quadrupole mass spectrometer with ion mobility spectrometry for improved plant lipidomics, 1726527, U.S. National Science Foundation (United States, Alexandria) - NSF
Kansas IDeA Network of Biomedical Research Excellence (K-INBRE), P20GM103418, National Institutes of Health (United States, Bethesda) - NIH
Lipids in Plants: Improving and Developing Sustainability of Crops, 1013013, National Institute of Food and Agriculture (United States, Washington) - NIFA
Grant note: The lipid profile data were acquired at Kansas Lipidomics Research Center (KLRC). Instrument acquisition and method development at KLRC were supported by NSF grants MCB 0455318, MCB 0920663, DBI 0521587, DBI 1228622, Kansas INBRE (NIH Grant P20 RR16475 from the INBRE program of the National Center for Research Resources), NSF EPSCoR grant EPS-0236913, Kansas Technology Enterprise Corporation, and Kansas State University.
Language: English
Date collected: 01/31/2016–04/25/2019
Date published: 04/01/2024
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program
Record Identifier: 9984571553602771

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Datasets for Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice

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