Dataset
Datasets for Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice
University of Iowa
04/01/2024
DOI: 10.25820/data.006915
Abstract
This dataset includes lipidomic analyses from a study investigating the toxicity of the Fox River Mixture (FRM), an environmental polychlorinated biphenyl (PCB) mixture, in adult conventional and germ-free mice (Cheng et al., 2018; Li et al., 2022; Lim et al., 2020). The mice were exposed orally once daily for 3 consecutive days to the FRM at a low dose (6 mg per kg body weight) and a high dose (30 mg per kg body weight). The control group was exposed to the vehicle (corn oil) alone. This dataset includes polar lipids, fatty acids incorporated into triacylglycerides, and triacylglyceride levels, expressed as signal per milligram protein. The original analytical data and LC-MS spectra of both polar lipids and TAG are also included as compressed Excel files. In addition, the extractable lipid content is reported for the lung, brain, jejunum, duodenum, ileum, stomach, cecum, colon, muscle, kidney, liver, and heart from naïve conventional and germ-free mice. These tissues were generated as part of published animal studies(Fu et al., 2021; Selwyn et al., 2015).
Details
- Title: Subtitle
- Datasets for Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice
- Creators
- Xueshu Li - University of Iowa, Occupational and Environmental HealthHui Wang - University of Iowa, Occupational and Environmental HealthHui Wang - University of Iowa, Occupational and Environmental HealthAmanda J Bullert - University of Iowa, Occupational and Environmental HealthJulia Yue Cui - University of WashingtonKai Wang - Institute for Systems BiologyHans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
- Contributors
- Brian Westra (Contributor) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
- Resource Type
- Dataset
- DOI
- 10.25820/data.006915
- Publisher
- University of Iowa
- Grants
- Grant note
- The lipid profile data were acquired at Kansas Lipidomics Research Center (KLRC). Instrument acquisition and method development at KLRC were supported by NSF grants MCB 0455318, MCB 0920663, DBI 0521587, DBI 1228622, Kansas INBRE (NIH Grant P20 RR16475 from the INBRE program of the National Center for Research Resources), NSF EPSCoR grant EPS-0236913, Kansas Technology Enterprise Corporation, and Kansas State University.
- Language
- English
- Date collected
- 01/31/2016–04/25/2019
- Date published
- 04/01/2024
- Academic Unit
- Occupational and Environmental Health; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program
- Record Identifier
- 9984571553602771
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