Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice

Amanda J Bullert; Hui Wang; Anthony E Valenzuela; Kari Neier; Rebecca J. Wilson; Jessie R Badley; Janine M LaSalle; Xin Hu; Pamela J Lein; Hans-Joachim Lehmler

doi:10.25820/data.007310

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Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice

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Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice

Amanda J Bullert, Hui Wang, Anthony E Valenzuela, Kari Neier, Rebecca J. Wilson, Jessie R Badley, Janine M LaSalle, Xin Hu, Pamela J Lein and Hans-Joachim Lehmler

University of Iowa

11/18/2024

DOI: 10.25820/data.007310

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List of identifiers for the substances used in this study.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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Abstract

This dataset includes the data from a study investigating the interactions of polychlorinated biphenyls (PCBs) and their metabolites with the brain and liver transcriptome of female mice. Female C57BL/6J mice (> 6 weeks) were orally exposed for 7 weeks to a human-relevant PCB mixture (MARBLES mix) at 0, 0.1, 1, and 6 mg/kg body weight/day. PCB and OH-PCB levels were quantified in the brain, liver, and serum; RNA sequencing was performed in the striatum, prefrontal cortex, and liver, and metabolomic analyses were performed in the striatum. Network analysis was performed to characterize interactions between individual PCBs and their metabolites and specific differentially expressed genes (DEGs).

Brain

Gene Expression

Metabolism

Metabolites

PCBs

Polychlorinated biphenyls

Mice

Liver

Toxicity

Transcriptome

Details

Title: Subtitle: Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice
Creators: Amanda J Bullert
Hui Wang - University of Iowa, Occupational and Environmental Health
Anthony E Valenzuela - University of California, Davis
Kari Neier - University of California Davis Medical Center
Rebecca J. Wilson - University of California, Davis
Jessie R Badley - University of California, Davis
Janine M LaSalle - University of California, Davis
Xin Hu - Emory University
Pamela J Lein - University of California, Davis
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Contributors: Brian Westra (Contributor) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.007310
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES), R01ES029213, National Institutes of Health (United States, Bethesda) - NIH
UC Davis Environmental Health Sciences Core Center, P30ES023513, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 01/01/2019–12/31/2023
Date published: 11/18/2024
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program
Record Identifier: 9984656011302771

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Interactions of polychlorinated biphenyls and their metabolites with the brain and liver transcriptome of female mice

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