Dataset
Metabolite Perturbations in Type 1 Diabetes Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease
figshare
04/28/2025
DOI: 10.6084/m9.figshare.28882964
Abstract
To evaluate MASLD in T1D, we conducted a cross-sectional study. Participants with T1D were stratified as MASLD (cases) or controls, dependent on the results determined by FibroScan imaging. Key fasting intermediary metabolites, lipid species, and acylcarnitines were measured.Given the lack of information regarding MASLD in type 1 diabetes and knowing that a substantial subset of individuals with type 1 diabetes are overweight or obese, we hypothesized that a random sample of participants with T1D would have a high prevalence of MASLD and those with MASLD would exhibit metabolites associated with insulin resistance including ceramides, glutamate, branched chain amino acids, and aromatic amino acids. We further hypothesize that these metabolites would correlate with the severity of MASLD as determined by FibroScan imaging.
Details
- Title: Subtitle
- Metabolite Perturbations in Type 1 Diabetes Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease
- Creators
- Adeyinka TaiwoRonald A MerrillLinder WendtDaniel PapeHimani ThakkarAlan MaschekJames CoxScott A SummersBhagirath ChaurasiaNikitha PothireddyBianca CarlsonAntonio SanchezPatrick Ten EyckDiana JalalAyotunde DokunEric B TaylorWilliam Sivitz
- Resource Type
- Dataset
- DOI
- 10.6084/m9.figshare.28882964
- Publisher
- figshare
- Language
- English
- Date published
- 04/28/2025
- Academic Unit
- Molecular Physiology and Biophysics; Gastroenterology and Hepatology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; Nephrology; Endocrinology and Metabolism; Internal Medicine; Design Biostat and Ethics
- Record Identifier
- 9984824331302771
Metrics
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