Synthesis and Characterization of Alzheimer’s Disease and Related Dementias (ADRD) Mixture

Xueshu Li; Hans-Joachim Lehmler

doi:10.25820/data.007553

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Synthesis and Characterization of Alzheimer’s Disease and Related Dementias (ADRD) Mixture

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Synthesis and Characterization of Alzheimer’s Disease and Related Dementias (ADRD) Mixture

Xueshu Li and Hans-Joachim Lehmler

University of Iowa

04/25/2025

DOI: 10.25820/data.007553

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READMEDescribes the files in the dataset, methods, suggested citation, research funding, and other details.Open Data Commons Attribution (ODC-By) V1.0, Open Access

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D1_mass-transition3.40 kBDownload View

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D2_mass_profiles5.64 kBDownload View

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D3_mass_profile_ADRD5.48 kBDownload View

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Abstract

Polychlorinated biphenyls (PCBs) are a group of man-made organic chemicals linked to various adverse human health effects, including cancer, immune system suppression, and neurotoxicity. To replicate the average PCB profile found in human brain tissues from 72 healthy donors, an Alzheimer’s Disease and Related Dementias PCB Mixture (ADRD mixture) was prepared using 4 Aroclors (5% Aroclor 1242, 19% Arolcor 1248, 30% Aroclor 1254, 32% Aroclor 1260) and 2 specific PCB congeners (8% PCB28 and 6% PCB160) by mass percentage. This dataset includes the mass profiles of the 4 Aroclors adopted from the previous publication (Frame et al., 1996; Schulz et al., 1989) and the synthesized ADRD mixture. The ADRD mixture was characterized by using a PCB congener-specific analysis method with gas chromatography-tandem mass spectrometry (GC-MS-MS) in the multiple reaction monitoring (MRM) mode(Li et al., 2022). The mass transition method setting and the corresponding raw data acquired from GC-MS-MS instrument are also included.

Dementia

Alzheimer's Disease

Polychlorinated Biphenyls

PCBs

Neurotoxicity

GC-MS-MS

Multiple Reaction Monitoring

Congener-specific analysis

Brain Tissue

Details

Title: Subtitle: Synthesis and Characterization of Alzheimer’s Disease and Related Dementias (ADRD) Mixture
Creators: Xueshu Li - University of Iowa, Occupational and Environmental Health
Hans-Joachim Lehmler - University of Iowa, Occupational and Environmental Health
Contributors: Brian Westra (Data Curator) - University of Iowa, Humanities and Social Sciences/Scholarly Impact
Resource Type: Dataset
DOI: 10.25820/data.007553
Publisher: University of Iowa
Grants: Airborne PCBs: Sources, Exposures, Toxicities, Remediation, P42ES013661, National Institutes of Health (United States, Bethesda) - NIH
Environmental Health Sciences Research Center, P30ES005605, National Institutes of Health (United States, Bethesda) - NIH
PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?, R01ES031098, National Institutes of Health (United States, Bethesda) - NIH
Molecular and Cellular Basis of PCB Developmental Neurotoxicity, R01ES014901, National Institutes of Health (United States, Bethesda) - NIH
Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction, R01ES034691, National Institutes of Health (United States, Bethesda) - NIH
Language: English
Date collected: 05/01/2023–07/01/2023
Date published: 04/25/2025
Academic Unit: Public Health Administration; Occupational and Environmental Health; Iowa Neuroscience Institute; Humanities and Social Sciences/Scholarly Impact; Iowa Superfund Research Program
Record Identifier: 9984800304302771

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