This study examines international graduate students’ cross-cultural adaptation in the U.S., using Núñez’s (2014) multilevel model of intersectionality as the theoretical framework. It explores how students described their adaptation experiences, including the challenges they faced and strategies they adopted. The study also investigates the roles of the University and its staff in influencing students’ adaptation. Fourteen international graduate students and seven staff members from a Midwestern U.S. university participated. Data were collected through student responses to a Qualtrics survey, interviews with both students and staff members, and observations of two orientation sessions for international graduate students. Guided by Núñez’s model, the analysis showed that students, grouped by nation of origin, language, cultural background, and acculturation approach, experienced various language-related and non-language challenges in both academic and daily life. They addressed these challenges with distinct strategies. This study also adapted Núñez’s model by demonstrating the reciprocal relationship between institutional and staff support and students’ adaptation. For example, while institutional services and staff support contributed to students’ adaptation, students’ reflections on their limited engagement with some services revealed structural issues in how they were organized and implemented. Moreover, staff members not only provided support based on their perspectives but also offered more tailored support by identifying and responding to students’ needs. The study offers practical implications for universities, faculty, and staff working to support international students’ cross-cultural adaptation, and helps prospective international students better prepare for their transition to graduate study in the U.S.