Application of miR-200c for regenerative endodontics

microRNAs (miRs) play an important role in post-transcriptional regulation in inflammation and regeneration and have emerged as innovative tools for the diagnosis and treatment of disease. miR-200c has previously been demonstrated to potently regulate tooth development, modulate inflammation, and promote osteogenesis, and could also be a candidate to assist in regenerative endodontic procedures. Therefore, my research focuses on characterizing miR-200c in tooth inflammation to determine its potential in attenuating inflammation and promoting odontogenesis in dental pulp stem cells. Our findings revealed that plasmid DNA encoding miR-200c using non-viral transfection methods may potentially be used as therapeutic approaches for vital pulp therapy and endodontic regeneration by attenuating inflammation and promoting odontogenic differentiation. As a dental clinician, I aspire to incorporate novel research approaches such as these into innovative clinical therapies to treat and restore inflamed teeth ultimately improving their long-term survival.