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Background: Rehabilitation from medial patellofemoral ligament reconstruction typically uses a well-defined protocol, resulting in positive outcomes for patients. However, there is limited research investigating rehabilitation protocols for those with Ehlers-Danlos syndrome following MPFL reconstruction. Purpose: The purpose of this case is to highlight the unique challenges faced when rehabilitating a patient post-MPFLR with systemic ligament laxity due to Ehlers-Danlos syndrome. Case Description: The patient is a 16-year-old female post medial patellofemoral ligament reconstruction and previous medical history including Ehlers-Danlos Syndrome, which adds complexity to rehabilitation. Interventions included gaining knee range of motion and strengthening knee and hip musculature to improve functional mobility. Outcomes: The patient was treated for a total of 8 weeks with a range of motion improvement of 42 degrees of knee flexion, as well as overall improvement of lower extremity strength and functional mobility. Discussion: Although there are many interventions used to rehabilitate a juvenile patient following medial patellofemoral reconstruction, there is little information to help guide therapists when dealing with multiple comorbidities.