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Background: Lower extremity amputation is a common complication of traumatic injury, cardiovascular disease, and diabetes mellitus. Following lower extremity amputation, functional mobility is often severely impaired. The use of prosthetic devices can be used to ameliorate mobility impairments; however medical and financial concerns can prevent administration of a lower extremity prosthesis. Case Description: The following case describes the treatment of a 57-year-old-man following below knee amputation (BKA) due to non-healing diabetic wounds with care complicated by numerous metabolic and cardiovascular comorbidities and functional deconditioning after multiple acute hospital readmissions due to infection. Intervention: Strength training, functional mobility training, repetitive task practice, and administration of assistive devices including bed loops, push-up bars, transfer board, and wheelchair were utilized during care. Outcome Measures: Outcome measures completed during this treatment course include Amputee Mobility Predictor (AMP), Modified Functional Reach Test, and Section GG functional measure of the Inpatient Rehab Facility Patient Assessment Instruments (IRF-PAI) as mandated by the IMPACT Act. Discussion: Physical therapy plays a significant role in the rehabilitation and mobility status of patients following BKA. Many strategies may be used to improve functional mobility. Adaptive strategies include the use of equipment and compensations; while restorative strategies are focused on improving strength, endurance, and skill with activities. There is currently little evidence highlighting the decision-making process in which strategies to employ to improve the functional independence of a patient following BKA. It is the purpose of physical therapy to improve the mobility and independence of patients through a combination of adaptive and restorative strategies.