Firearm-related suicides are injury deaths that result from injuring oneself using a firearm with the intention of dying. Firearm-related suicides have been increasing in the US, and workers in farming and law enforcement are at higher risk for firearm-related suicide. However, less is known about rates of firearm-related suicide by occupational groups and how job factors including having access to firearms at work and job strain (also known as job stress) contribute to suicide risk. This study sought to identify which worker populations have the highest rates of firearm-related suicide and how access to firearms at work and job strain contribute to the odds of dying from firearm-related suicide. Worker populations with the highest rates of firearm-related suicide were in protective services (males: 21.7 per 100,000 workers; females: 7.9 per 100,000 workers); farming, fishing, and forestry (males only: 18.3 per 100,000 workers); construction and extraction (males: 25.9 per 100,000 workers; females: 7.2 per 100,000 workers); and installation, maintenance, and repair (males: 23.7 per 100,000 workers; females: 6.2 per 100,000 workers). Access to firearms at work increased the odds of dying from firearm-related suicide for male (OR = 2.2; 95% CI, 2.0, 2.5) and female (OR = 3.0; 95% CI, 2.4, 3.8) decedents. Additionally, decedents who worked in a high-strain job (i.e., having high job demands and low job control) and had access to firearms at work had an increased odds of firearm-related suicide for male (OR = 2.4, 95% CI: 1.9, 3.0) and female (OR = 4.0, 95% CI: 2.4, 6.5) decedents, compared to having no access to firearms at work and working in a low-strain job (i.e., having low job demands and high job control). These findings suggest that workers in protective services and farming, fishing, and forestry occupations should be the focus of firearm-related suicide prevention strategies.