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Background: Rhabdomyolysis (RM) is a condition that is the result of muscle breakdown, typically occurring in cases of over-exertion, immobility, or trauma. Symptoms of RM include edema, weakness, stiffness, and painful mobility. The purpose of this case study is to describe the successful implementation of physical therapy (PT) interventions in a patient hospitalized with RM secondary to opioid overdose. The patient’s clinical findings, intervention timeline, and outcomes will be discussed in this case report. Case Description: The patient is a 48-year-old female who was admitted to the hospital following opioid overdose. The patient was diagnosed with opioid-induced RM and acute kidney injury. The patient was hospitalized for 3-weeks before discharging home with home care. Outcome Measures: The patient scored 11 on the AM-PAC Basic Mobility on initial evaluation and was able to improve score to 23 at discharge. Additionally, the patient’s bed mobility, transfers, gait, and stair negotiation significantly improved throughout hospital stay. Discussion: Evidence-based researched is limited regarding PT treatment in patients with RM. This patient demonstrated improved functional mobility throughout hospital stay, however, continued to be limited due to pain in bilateral lower extremities. Thorough sensory testing should be administered and monitored throughout the hospital length of stay.