Dissertation
Risk factors for oral cancer in Nepalese population: a hospital based case-control study
University of Iowa
Doctor of Philosophy (PhD), University of Iowa
Autumn 2020
DOI: 10.17077/etd.005684
Abstract
Few reports show the changing trend of oral cancer (OC) in Nepal. The literature on the risk behavior of OC in the Nepalese population is limited. This study investigated the risk factors for OC in patients visiting a tertiary referral hospital in central Nepal. A case-control study of adults aged 18 and above was conducted from June 2019 to August 2019. Cases and controls were age and gender-matched and were selected from the same hospital. A structured questionnaire was used to explore exposure to tobacco and non-tobacco products, including alcohol. The study enrolled a total of 272 subjects with 204 male and 68 female subjects with a mean age of 57.1 years. The majority of the subjects were 41 years old or higher (91.9%). Tobacco smoking was associated with an increased risk of OC (adjusted OR 2.2, 95% CI 1.1-4.3). The risk of OC increased with smoking pack-years for the 10-19 category (adjusted OR 8.7, 95% CI 2.3–32.9). There was a significant association between the number of years smoked and OC (30-50 years group, adjusted OR 5.2, 95% CI 2.1-12.8). Types of tobacco use (filter and non-filter) were also associated with the risk of OC (adjusted OR 2.2, 95% CI 1.2-6.7). Similarly, the consumption of smokeless tobacco products was higher in cases compared to controls (68.4 % vs. 35.3%). Types of chewing products (Gutka, Surti, moist tobacco) were associated with the occurrence of oral cavity cancer with varying adjusted OR ranging from 1.9 to 29.1. The frequency of chewing products used per day was also associated with OC. The higher the frequency of chewing products, the greater was the risk for oral cancer. People who consumed alcohol in the past were associated with OC (adjusted OR 8.7, 95% CI 2.3–32.9). Drinking years 10-19 and 20-29 were also associated with OC. Our study showed that smoking, smokeless tobacco, and alcohol increase the risk of OC in the Nepalese population. The findings from this project allow public health officials in Nepal to understand the risk factors for OC and address these issues with appropriate intervention programs.
Details
- Title: Subtitle
- Risk factors for oral cancer in Nepalese population: a hospital based case-control study
- Creators
- Kiran Sapkota
- Contributors
- Prajwal Gurung (Advisor)Catherine H Cherwin (Committee Member)Hari P Sharma (Committee Member)Robert W. Buckingham (Committee Member)Rup K Sainju (Committee Member)Ajit Vikram (Committee Member)
- Resource Type
- Dissertation
- Degree Awarded
- Doctor of Philosophy (PhD), University of Iowa
- Degree in
- Interdisciplinary Studies (Cancer Epidemiology)
- Date degree season
- Autumn 2020
- DOI
- 10.17077/etd.005684
- Publisher
- University of Iowa
- Number of pages
- 147 pages
- Copyright
- Copyright 2020 Kiran Sapkota
- Language
- English
- Description illustrations
- color illustrations, color maps
- Description bibliographic
- Includes bibliographical references (pages 93-120).
- Academic Unit
- Interdisciplinary Studies Program
- Record Identifier
- 9984036085802771
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