Background: Depression is a common comorbidity seen in children with epilepsy. Unidentified, it can contribute to decreased quality of life and impact their seizure control. The Neurological Disorders Depression Inventory-Epilepsy-Youth (NDDI-E-Y) is a short, population-specific, validated depression screening tool that was implemented in a Neurology Clinic within a Pediatric Specialty Clinic. Purpose: The purpose of this project was to implement an evidence-based depression screening tool for children with epilepsy and refer patients with positive screens to mental health providers. Methods: This quality improvement project implemented an evidence-based depression screening tool for children aged 12-17 years with an epilepsy diagnosis. Children with a positive screening, defined as greater than or equal to 32, were referred to mental health services. A pre- and post-implementation survey was administered to providers who see children with epilepsy to assess their confidence levels identifying and managing depression in this population. Findings: Over a 12-week implementation period, 176 children met criteria to be screened with the NDDI-E-Y. Of that, 36% (n = 63) eligible patients completed the screening tool. There were no positive screenings and therefore no mental health referrals during the implementation period. Discussion: The implementation of this project showed clinical significance as there was a 36% increase in patients screened for depression compared to zero patients being routinely screened pre-implementation. There was an increase in confidence levels of providers when comparing the pre-implementation mean (2.18) and post-implementation mean (2.63) in identifying and managing depression in this population. This ensures providers are becoming more aware of the high prevalence of depression in their patient population and are acknowledging the utilization of the NDDI-E-Y in their clinic. Although zero children screened positive, this evidence-based tool will continue to screen for depression in children with epilepsy.