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Background: Rotator cuff injuries are among the most common types of injuries in professional baseball and account for the greatest amount of time missed from play. Blood flow restriction (BFR) therapy provides the opportunity to initiate hypertrophy and strength gains early in rehabilitation while minimizing unnecessary stress on healing tissues. BFR training aims to expedite both the rehabilitation process and return to play. However, this remains a relatively new intervention that is not well known to many physical therapists. Thus, the purpose of this case report is to highlight a patient who had a positive outcome using BFR during rehabilitation and to discuss the available research on this intervention. Case Description: The report follows a 21-year-old professional baseball pitcher who underwent BFR therapy as part of his treatment following a subscapularis strain. Outcome Measures: Following rehabilitation, the athlete’s shoulder strength and range of motion were found to be greater than 96% of the uninvolved limb. The athlete was discharged home with an offseason strength and interval throwing program. Discussion: This case study examines the current evidence on the topic of BFR training and demonstrates the safe use of the intervention in a professional baseball setting.