Suicide is the 11th leading cause of death in the United States, and rates are rising each year. Negative life events such as financial strain and relationship conflicts are associated with an increased risk of suicide, especially in the days or weeks immediately after they occur. We define this acute period as a crisis, but little is known about how crises co-occur and develop in real-world cases. Additionally, it remains unclear whether suicide prevention efforts are effective at addressing crises. The purpose of this dissertation was to better understand the details and overlap of crises preceding suicide, and to evaluate the availability of targeted interventions. We identified six patterns of crises among people who died by suicide, including (1) co- occurring substance use, alcohol, relationship, and eviction (2) physical health (3) criminal (4) co-occurring job, financial, and intimate partner (5) intimate partner and (6) “other” crises. Analysis of real-world suicide narratives highlighted that each of these crises encompass a diverse array of situations and stressors. We also identified 35 reviews on suicide prevention targeting intimate partner violence, physical health problems, suicide bereavement, financial problems, housing, disaster exposure, incarceration, and job problems. However, no review was able to draw solid conclusions about which interventions may be effective and evidence remains limited. These findings highlight the need for suicide prevention efforts that go beyond single risk factors to address overlapping crises. Future research should prioritize the implementation of interventions that recognize and address the complexity of the life circumstances that lead to suicide.