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Background: Hundreds of thousands of anterior cruciate ligament (ACL) injuries occur every year, thousands of which are combination injuries with damage to multiple ligaments. Despite advances in surgical and rehabilitative interventions the rate of reinjury in this patient population remains high. While there is a growing amount of return to sport guidelines being published in the literature, there lacks a consensus on which is best. The purpose of this case study was to investigate the use of clinical movement screening tests to assess the return to sport readiness of a patient with a multi-ligament knee injury. Case Description: The patient was a 17-year-old male soccer player who sustained ACL, medial collateral ligament (MCL) and meniscus tears due to a contact injury while playing football. The patient underwent surgery for ACL reconstruction, MCL reconstruction and meniscal repair. The patient worked with therapy for over 12 months with an extended return to sport phase focused on functional strengthening, plyometrics, agility and neuromuscular training. Outcome Assessments: The move2perform tool was utilized, which combines the results of the Functional Movement Screen, the Lower Quarter Y Balance Test and Functional Hop Testing to assess risk of future injury. A checklist developed by the clinic to test neuromuscular control was also used. Discussion: This case report describes the effectiveness of using a combination of multiple movement screening tests to assist with guiding interventions and return to sport decision making. Research studies evaluating the validity of these movement screens to assess the risk of future injury show mixed results. Future research studies should investigate the validity of movement screens to specifically assess risk of reinjury in patients with multi-ligament knee injuries.