Editorial
Cytolysins, superantigens, and pneumonia due to community-associated methicillin-resistant Staphylococcus aureus
The Journal of infectious diseases, Vol.200(5), pp.676-678
09/01/2009
DOI: 10.1086/605333
PMCID: PMC2945255
PMID: 19653828
Abstract
This editorial evaluates data in an accompanying manuscript by Hongo et al. and includes comparison to other published data on virulence factors (cytolysins and superantigens) associated with or contributing to severe pulmonary diseases caused by methicillin-resistant Staphylococcus aureus (MRSA). The major conclusion of the Hongo et al. article is that studies to assess cytolysin functions in serious human MRSA infections must use non-murine models, since cytolysins, such as Panton-Valentine leukocidin (PVL), have limited activity in killing mouse polymorphonuclear leukocytes (PMNs), compared to killing human PMNs.
Details
- Title: Subtitle
- Cytolysins, superantigens, and pneumonia due to community-associated methicillin-resistant Staphylococcus aureus
- Creators
- Patrick M Schlievert
- Resource Type
- Editorial
- Publication Details
- The Journal of infectious diseases, Vol.200(5), pp.676-678
- Publisher
- United States
- DOI
- 10.1086/605333
- PMID
- 19653828
- PMCID
- PMC2945255
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Grant note
- R01 AI074283 / NIAID NIH HHS U54 AI057153 / NIAID NIH HHS R01 AI074283-23 / NIAID NIH HHS U54 AI057153-075876 / NIAID NIH HHS R01 HL036611 / NHLBI NIH HHS AI074283 / NIAID NIH HHS
- Language
- English
- Date published
- 09/01/2009
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001208902771
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