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Editorial: Forebrain control of breathing and sudden death in epilepsy
Editorial   Open access

Editorial: Forebrain control of breathing and sudden death in epilepsy

Steven Crone, Brian Dlouhy, Christina Gross and Russell Ray
Frontiers in neural circuits, Vol.17, 1212172
05/23/2023
DOI: 10.3389/fncir.2023.1212172
PMCID: PMC10242160
PMID: 37288286
url
https://doi.org/10.3389/fncir.2023.1212172View
Published (Version of record) Open Access

Abstract

[...]prior studies have shown that some epilepsy patients have a decreased ability to respond to increased levels of carbon dioxide in the blood, which correlates with longer episodes of respiratory depression following a seizure (Sainju et al., 2019). Hampson et al. use functional magnetic resonance imaging (fMRI) to examine changes in brain activity during increased CO2 exposure in persons with epilepsy compared to healthy controls. There are currently no therapeutic approaches to prevent SUDEP and research in this area presents many challenges, including difficulty assessing which patients are at risk, insufficient understanding of the underlying mechanisms, a lack of animal models to recapitulate all aspects of SUDEP, and the diversity of patients at risk for SUDEP. Epilepsia 55, 1479–1485. doi: 10.1111/epi.12666 Steven A. Crone1,2,3*, Brian J. Dlouhy4,5,6, Christina Gross7,8 and Russell S. Ray9,10,11 * 1Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States * 2Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States * 3Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States * 4Department of Neurosurgery, University of Iowa, Iowa City, IA, United States * 5Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, United States * 6Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, United States * 7Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States * 8Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States * 9Memory Brain Research Center, Baylor College of Medicine, Houston, TX, United States *
 Animal Models Carbon Dioxide Children & Youth Developmental Biology Epilepsy Health Care Magnetic Resonance Imaging Nervous System Neuroimaging Neurosurgery Pediatrics Airway management Brain mapping Brain research Children Convulsions & seizures Forebrain Functional magnetic resonance imaging Patients Prevention Seizures Sleep

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