Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity

Lalit Batra; Shilpi Giri; Shailesh Shahi

doi:10.3389/fimmu.2025.1759310

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Editorial

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Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity

Lalit Batra, Shilpi Giri and Shailesh Shahi

Frontiers in immunology, Vol.16, 1759310

01/01/2026

DOI: 10.3389/fimmu.2025.1759310

PMCID: PMC12813188

PMID: 41562088

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Abstract

[...]most of the provided preclinical data lacks interactions with conventional RA therapies, long-term effects and human trials to test efficacy and safety. Macrophage and hypertension research from 2015–2024 Wang et al.conducted a bibliometric and visualization analysis of the literature on macrophages and hypertension research published in last 10 years. Conclusions, future directions, and acknowledgments In summary, the articles published in this Research Topic advance our understanding of TRMs interaction, function, and their important roles in immune regulation, disease development and therapeutics intervention. [...]introduction of innovative approaches such as genomic, transgenic, and advanced immunological technique further expands conceptual, mechanistic, and theoretical knowledge in the TRMs biology.

Asthma

Autoimmunity

Clinical Trials

Cytokines

Disease

Heart Failure

Hypertension

Immune System

Immunoregulation

Inflammation

Metabolites

Bibliometrics

Conflicts of interest

Drug development

Editing

Generative artificial intelligence

Homeostasis

Immunity (Disease)

Infections

Long-term effects

Macrophages

Medical prognosis

Rheumatoid arthritis

Writing

Details

Title: Subtitle: Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity
Creators: Lalit Batra - University of Louisville
Shilpi Giri - University of Pittsburgh
Shailesh Shahi - University of Iowa
Resource Type: Editorial
Publication Details: Frontiers in immunology, Vol.16, 1759310
DOI: 10.3389/fimmu.2025.1759310
PMID: 41562088
PMCID: PMC12813188
NLM abbreviation: Front Immunol
ISSN: 1664-3224
eISSN: 1664-3224
Publisher: Frontiers Media SA
Grant note: National Multiple Sclerosis Society: RG-2407-43720 Congressionally Directed Medical Research Programs: HT94252510562
The author(s) declared that financial support was received for work and/or its publication. The Author acknowledge funding from the National Multiple Sclerosis Society grant (RG-2407-43720), and the Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP) grant (HT94252510562) to S.K.S.
Language: English
Date published: 01/01/2026
Academic Unit: Pathology; Iowa Neuroscience Institute
Record Identifier: 9985116069902771

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