Editorial
Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus
mBio, Vol.4(1), p.e00002-13
01/15/2013
DOI: 10.1128/mBio.00002-13
PMCID: PMC3551544
PMID: 23322635
Abstract
A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in mBio, Müller et al. described several important differences between the two viruses [M. A. Müller et al., mBio 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions.
Details
- Title: Subtitle
- Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus
- Creators
- Stanley Perlman - Department of Microbiology, University of Iowa, Iowa City, Iowa, USAJincun Zhao
- Resource Type
- Editorial
- Publication Details
- mBio, Vol.4(1), p.e00002-13
- DOI
- 10.1128/mBio.00002-13
- PMID
- 23322635
- PMCID
- PMC3551544
- NLM abbreviation
- mBio
- ISSN
- 2161-2129
- eISSN
- 2150-7511
- Publisher
- United States
- Grant note
- P01 AI060699 / NIAID NIH HHS R01 AI091322 / NIAID NIH HHS
- Language
- English
- Date published
- 01/15/2013
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777355502771
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