Encyclopedia entry
Drug Priming
Encyclopedia of Behavioral Neuroscience, Three-Volume Set, 1- 3, pp.431-436
2010
DOI: 10.1016/B978-0-08-045396-5.00066-X
Abstract
A hallmark of drug addiction and the major problem facing the treatment of drug addiction is the high propensity to relapse. Drug-induced relapse is a common mechanism for relapse and has been modeled in animals. From animal studies investigating drug-induced relapse, it has become clear that the mechanisms underlying relapse are not identical to those underlying the rewarding effects of the drug itself and depend on changes in neural systems mediating decision making and motor output. Enduring alterations in the glutamatergic pathway from the prefrontal cortex to the nucleus accumbens underlie relapse to drug seeking, and when an animal is given a small amount of the drug of abuse, these alterations enable the drug to drive compulsive drug-seeking behavior.
Details
- Title: Subtitle
- Drug Priming
- Creators
- R.T LaLumiereP.W Kalivas
- Resource Type
- Encyclopedia entry
- Publication Details
- Encyclopedia of Behavioral Neuroscience, Three-Volume Set, 1- 3, pp.431-436
- DOI
- 10.1016/B978-0-08-045396-5.00066-X
- Language
- English
- Date published
- 2010
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070489602771
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